Janssen Pharmaceutical Company

Fentanyl was introduced to the United States in 1968 by the Janssen Pharmaceutical Company and marketed under the trade name Sublimaze. Its primary purpose was for use as an intravenous anesthetic and analgesic. It is 100 times more potent than morphine in reducing pain, and its duration of action is only 30 minutes (compared to morphine, which lasts several hours). Over the years, fentanyl has proved to be an extremely useful drug, and to date, it is still widely used for surgeries, childbirth, pain associated with cancer and other diseases, and the treatment of trauma-related injuries. Although fentanyl solutions are often given intravenously, pill forms of the drug are also available. 

Janssen-Pharmaceutical Companies of J J, Tumhoutseweg 30, 2340 Beerse, Belgium e-mail yhoupis its.jnj.com... 

Janssen Pharmaceutical Companies of Johnson Johnson B-2340 Beerse, Belgium... 

Due to the success of fentanyl, Janssen and other pharmaceutical companies started to produce other legal fentanyl analogues with a wider range of potency and duration of action, including ... 

Union Chimique Beige was founded in 1928 by, among others, Baron Emmanuel Janssen, who was married to a granddaughter of Ernest Solvay, the founder of Sol-vay, the other Belgian hybrid chemical/pharmaceutical company. At that time, Union Chimique Beige was producing several heavy chemical intermediates such as ammonia, sulfuric acid, sodium sulfide, and coal derivatives. 

And while it is also true that thirty pharmaceutical companies alone account for 60 percent of worldwide ethical drug sales, the sums of money invested in research do not always get their full return. Thus it is that a small company like Janssen s laboratory, Janssen Pharmaceuticals, in Belgium, which was acquired in 1979 by Johnson and Johnson and which has among its discoveries diphenoxylate (1963) and loperamide (1975), has proved more innovative over the last fifteen years than the Rhone-Poulenc group, which has produced no major new molecule during the same time, although it devotes far more money to its research. 

The results of one of the clinical trials in which olanzapine (Eli Lilly) was compared with risperidone (Janssen Pharmaceutica) (SEDA-22, 64) gave rise to a debate between researchers of the two pharmaceuticals companies on some of the possible flaws (100-105). Since the modal dosage over the 28-week trial was 7.2 mg/day, significantly higher than that used in actual clinical practice (average dose 4.6 mg/day), the higher incidence of risperidone-associated adverse effects could have been explained by this dosage difference. 

Also known by its trade name Bethoguard from the producer Janssen pharmaceuticals, it has been promoted by companies like Ackros, with their grades Intercide BTX (Figure 39). 

China Otsuka Pharmaceutical Company Sino-American Shanghai Squibb Pharmaceutical Ltd Sino-Swedish Pharmaceutical Corporation Tianjin Smithkline and French Laboratories Xian Janssen Pharmaceutical Co. Ltd Beijing Zhongrui Ciba-Geigy Pharmaceutical Co. Ltd Chongqin Glaxo Pharmaceuticals Ltd Pfizer Pharmaceuticals Ltd... 

Janssen-Cilag applies (SoQ) for continuous self-improvement Janssen-Cilag is the pharmaceutical arm of the American Johnson Johnson Group of companies with their European Head Office based in High Wycombe, UK. Janssen-Cilag is among the top ten pharmaceutical companies in the world. 

---