Fentanyl citrate

The answer is c. (Hardman, pp 543—544. Katzang, p 2533) Fentanyl is a chemical relative of meperidine that is nearly 100 times more potent than morphine. The duration of action, usually between 30 and 60 min after parenteral administration, is shorter than that of meperidine. Fentanyl citrate is only available for parenteral administration intramuscularly and intravenously. Tran sbuc cal ( lollipop ) and transdermal patches avoid first-pass metabolism of fentanyl. 

Amoxicillin clavulanic acid Chlorthalidone Fentanyl citrate... 

Zhang J, Niu S, Maland LJ, Barrus BK, Freimann VR, Hague BI (1991b) Buccal permeability of oral transmucosal fentanyl citrate (OTFCTM) in a dog model. Pharm Res 8 S-155... 

Mystakidou K, Katsouda E, Parpa E, Vlahos L, and Tsitas ML (2006) Oral trans-mucosal fentanyl citrate Overview of pharmacological and clinical characteristics. Drug Deliv. 13 269-276. 

Fentanyl citrate—bupivacaine hydrochloride-epinephrine hydrochloride injection (100 mL)... 

Opoid anesthestics alfentanil hydrochloride fentanyl citrate remifentanil hydrochloride sufentanil citrate... 

Charge 2.6 g of fentanyl citrate into a pressure addition vessel and dissolve with stirring in 405.6 g of ethanol in which 0.26 g of oleic acid has previously been dissolved. After sealing and evacuation thereof, 6.7 kg of HFA 134a, which has previously been aerated with carbon dioxide... 

Coluzzi, P.H., et al. 2001. Breakthrough cancer pain A randomized trial comparing oral trans-mucosal fentanyl citrate (OTFC) and morphine sulfate immediate release (MSIR). Pain 91 123. 

Streisand, J.B., et al. 1991. Absorption and bioavailability of oral transmucosal fentanyl citrate. 

Fentanyl Care should be taken to avoid skin contact and inhalation of fentanyl citrate to prevent adverse effects. Incompatibility has been reported with other drugs such as thiopentone sodium, methohexitone sodium, and fluorouracil.54 This drug should not be administered along with alkaline drugs. 

Fentanyl citrate is stable if stored at room temperature up to 48 hours under normal conditions. Fentanyl should not be formulated with alkaline drugs and stored in PVC containers for product stability reasons. Formulations containing fentanyl and bupivacaine were found to be adsorbed in PVC containers. The formulation containing adrenaline or fentanyl citrate becomes degraded.55-57... 

Q.A. Xu, et al., Rapid loss of fentanyl citrate admixed with fluorouracil in PVC containers. Ann. Pharmacother. 31 297-302, 1997. 

S.R. Kowlski, and G.K. Gourlay, Stability of fentanyl citrate in glass and plastic containers and in a patient-controlled delivery system. Am. J. Hosp, Pharm. 47 1584-1587, 1990. 

Hypnorm (0.315 mg/mL fentanyl citrate and 10 mg/mL fluanisone Janssen Pharmaceutical Ltd., Grove, Oxford, UK). 

Caution. Avoid contact with skin and the inhalation of particles of fentanyl citrate. 

SYNS FENTANEST FENTANYL CITRATE LEPTANAL McN-JR 4263 MCN-JR-4263-49 PENTANYL N-(l-PHENETHYL-4-PIPERIDIN-YL)PROPIONANILIDE DIHYDROGEN CITRATE O N-(l-PHENETHYI 4-PIPERIDYL)PROPIONANIUDE CITRATE N-(l-PHENETHYL-4-PIPERID-YL)PROPIONANILIDE DIHYDROGEN CITRATE R 4263 R 5240 SUBLIMAZE SUBUMAZE CITRATE... 

Sometimes preanesthesia agents are used before cataract surgery. These agents help to relieve anxiety and to produce sedation and, in some cases, short-term amnesia. Oral or intravenous diazepam (Valium) or midazolam (Versed) or intravenous fentanyl citrate (Sublimaze) are commonly used for preoperative sedation. 

Fentanyl citrate is a sjmthetic opioid 1000 times more potent than pethidine. It has a relatively short duration of action, and its effects are rapidly reversed by opioid antagonists (1). It is useful (2) but has typical opioid adverse effects. 

Oral transmucosal fentanyl citrate has two advantages it is more acceptable as a flavored lozenge than an oral elixir or tablet would be, especially in children, and 25% goes directly into the systemic circulation without first-pass metabolism (SEDA-20, 77). Its main adverse effect is dose-dependent nausea and/or vomiting, which occurs in 25-50% of patients. In a double-blind, placebo-controlled comparison of oral transmucosal fentanyl citrate (10 pg/kg) and oral oxycodone (0.2 mg/kg) in outpatient wound care procedures in 22 children, there were similar outcomes and no adverse effects in either group (40). 

Sharar SR, Carrougher GJ, Selzer K, O Donnell F, Vavilala MS, Lee LA. A comparison of oral transmucosal fentanyl citrate and oral oxycodone for pediatric outpatient wound care. J Burn Care Rehabil 2002 23(1) 27-31. 

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