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Isotretinoin 13-cis-retinoic acid

Oral Isotretinoin (13-cis-retinoic acid) efficacy is based on its specific actions against all four factors implicated in acne pathogenesis. Isotretinoin targets are 1) sebum suppression ... [Pg.128]

All common types of acne can be treated with TCA. Severe acne, such as acne necrotica , acne conglobata or acne fulminans , should first be treated medically and the inflammation eliminated before the cosmetic use of peels. Oral isotretinoin (13-cis-retinoic acid) is the gold-standard treatment for severe acne (Box 13.1), but new retinoids come to light regularly. [Pg.102]

Retinoic acid (RA) describes a group of vitamin A acid (synonym Vitamin A1 acid) derivatives such as all-irans-retinoic acid (tretinoin), 9-cis-retinoic acid and 13-cis retinoic acid (isotretinoin). Retinoic acids act through binding to retinoic acid and retinoid X response elements. [Pg.1071]

There are many retinol containing preparations to treat vitamin deficiency states. Retinoids are also used to treat dermatological diseases like acne, psoriasis, Darier s disease, and ichthyosis. Tretinoin, all-trans-retinoic acid, is a topical preparation while isotretinoin or 13-cis-retinoic acid, and etretinate are available for oral administration. [Pg.476]

Retinoids in Dermatology 13-Cis-retinoic acid (isotretinoin, Accutane ) is used orally, and all-tram-retinoic acid (Tretinoin ) topictdly, for treatment of severely disfiguring cystic acne. Etretinate (the trimethoxyphenyl analog of retinoic acid) and ttizarotene (a receptor-specific retinoid) Me used topictdly for the treatment of psoriasis. They are effective in Ctises in which other therapy has ftuled, and at lower levels them Me required for the control of tumor development in experimental animals, although they have heen associated with hirth defects (Section 2.5.1.1 lohnson and ChtmdrMatna, 1999). [Pg.72]

Structures of 13-cis-retinoic acid (isotretinoin) (a) and etretinate (b), synthetic retinoids used as pharmacological agents,... [Pg.907]

Eckhoff, C. Chari, S. Kromka, M. Staudner, H. Juhasz, L. Rudiger, H. Agnish, N. Teratogenicity and transplacental pharmacokinetics of 13-cis-retinoic acid in rabbits. Toxicol.Appl.Pharmacol., 1994, 125, 34-41 [plasma acitretin (IS) SPE column temp 35 tissue extracted metabolites, isotretinoin, tretinoin]... [Pg.1232]

Ranalder, U.B. Lausecker, B.B. Huselton, C. Micro liquid chromatography-mass spectrometry with direct Uquid introduction used for separation and quantitation of all-(rans- and 13-cis-retinoic acids and their 4-oxo metabolites in human plasma. J.Chromatogr., 1993, 617, 129-135 [LC-MS LOQ 0.3 ng/mL extracted metabolites, isotretinoin, tretinoin]... [Pg.1233]

Tan, X. Meltzer, N. Lindenbaum, S. Solid-state stability studies of 13-cis-retinoic acid and all-tmns-retinoic acid using microcalorimetry and HPLC uialysis. Pharm.Res., 1992,9,1203-1208 [solutions simultaneous degradation products, isotretinoin, tretinoin]... [Pg.1233]

Shelley, R. Price, J.C. Jun, H.W. Cadwallader, D.E. Capomacchia, A.C. Improved and rapid high-performance liquid chromatographic assay for 13-cis-retinoic acid or all-trans-retinoic acid. J.Pharm.Sci., 1982, 71, 262-264 [rat serum extracted isotretinoin, retinol acetate, tretinoin, vitamin A pharmacokinetics LOQ 100 ng mL]... [Pg.1233]

Vane, F.M. Stoltenborg, J.K. Bugge, C.J. Determination of 13-cis-retinoic add and its major metabolite, 4-oxo-13-cis-retinoic acid, in human blood by reversed-phase high-performance liquid chromatography. J.Chromatogr, 1982, 227, 471-484 [gradient whole blood extracted metabolites, isotretinoin, tretinoin, vitamin A LOQ 10 ng/mL pharmacokinetics]... [Pg.1233]

Wyss, R. Bucheli, F. Determination of endogenous levels of 13-cis-retinoic acid (isotretinoin), aU-trans-retinoic acid (tretinoin) and their 4-oxo metabolites in human and animal plasma by high-performance liquid chromatography with automated column switching and liltraviolet detection, J.Chromatogr.B,... [Pg.23]

Retinoids have multiple properties in embriogenesis, growth control and differentiation of adult tissues, reproduction, and sight. In dermatology their use is well established for psoriasis, hereditary disorders of keratinization, acne, and skin aging. The most commonly used retinoids are aH-trans retinoic acid (tretinoin used topically), 13-cis retinoic acid [isotretinoin used both orally and topically), retinaldehyde/retinal and retinol [both of which are used topically). In addition there are the synthetic retinoids etretinate, acitretin, adapalene, tazarotene, etc. [Pg.13]

Creech Kraft J, Eckhoff Chr Kochhar DM, Bochert G, Chahoud I, Nau H (1991) Isotretinoin (13-d5-retinoic acid), metabolism, cis-trans isomerization, glucuronidation and transfer to the mouse embryo Consequences for teratogenicity. Teratogen Carcinogen Mutagen 11 21-30... [Pg.116]

Retention time 12.5 (isotretinoin), 12.7 (9-cis-retinoic acid), 13.5 (tretinoin)... [Pg.1231]

The development of biologically active, less-toxic synthetic derivatives of retinoic acid has lead to a major advance in dermatologic therapeutics. Isotretinoin (13-ci y-retinoic acid, Accutane) is the first of these synthetic retinoids to be marketed for the treatment of severe, recalcitrant cystic acne in the United States. [Pg.315]

JC Kraft, W Slikker, JR Bailey, LG Roberts, B Fischer, W Wittfoht, H Nau. Plasma pharmacokinetics and metabolism of 13-cis retinoic and iill-trans retinoic acid in the cynomolgus monkey and the identification of 13-cis retinoyl beta-glucuro-nides—a comparison to one human case-study with isotretinoin. Drug Metab Dispos 19 317-324, 1991. [Pg.84]

Up to now, far more than 5000 retinoic acid analogs have been synthesized, out of which the following three generations have been established for therapy of various disorders First, the nonaromatic retinoids (3-carotene (provitamin A), alWraras-retinoic acid (RA) (tretinoin) and 13-cis-RA (isotretinoin), second, the monoaromatic retinoid derivatives trimethyl-methoxyphenyl analog of RA (etretinate) and9-(4-methoxy-2,3,6-trimethylphenyl)-... [Pg.1072]

See other pages where Isotretinoin 13-cis-retinoic acid is mentioned: [Pg.227]    [Pg.2028]    [Pg.197]    [Pg.218]    [Pg.383]    [Pg.231]    [Pg.3654]    [Pg.218]    [Pg.365]    [Pg.365]    [Pg.703]    [Pg.227]    [Pg.2028]    [Pg.197]    [Pg.218]    [Pg.383]    [Pg.231]    [Pg.3654]    [Pg.218]    [Pg.365]    [Pg.365]    [Pg.703]    [Pg.12]    [Pg.1061]    [Pg.475]    [Pg.138]    [Pg.383]    [Pg.373]    [Pg.1233]    [Pg.224]    [Pg.258]    [Pg.58]    [Pg.1597]    [Pg.1597]    [Pg.58]    [Pg.1233]   


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13-cis-Retinoic acids

Isotretinoin

Retinoic

Retinoic acid

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