Isoprostane

Thompson HJ, Heimendinger J, Sedlacek S, Haegele A, Diker A, O Neill C, Meinecke B, Wolfe P, Zhu Z and Jiang W. 2005. 8-Isoprostane F2a excretion is reduced in women by increased vegetable and fruit intake. Am J Clin Nutr 82(4) 768-776. 

Vassalle C, Botto N, Andreassi MG, Berti S, Biagini A (2003) Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease. Coron Artery Dis 14 213-218... 

Antczak, A., Montuschi, P., Kharitonov, S., Gorski, P., and Barnes, P. J. (2002) Increased exhaled cysteinyl-leukotrienes and 8-isoprostane in aspirin-induced asthma. Am. J. Respir. Crit. Care Med. 166, 301-306. 

Fig. 65. Relationship between urinary 8-isoprostane and serum creatinine levels. In the initial phase, when the serum creatinine level was high, there was no increase in urinary 8-isoprostane. In the recovery phase, the urinary 8-isoprostane level increased...

S-Serum chemistry+CPK+myoglobin+8-isoprostane U-Urinechemistry+CPK+myoglobin+8-isoprostane 400-m sprint... 

We selected one renal hypouricemia patient with a history of ALPE and one healthy adult (control) without a history of ALPE, and measured creatinine clearance, FEUA, and oxidative stress markers (urinary 8-isoprostane and NOx) after anaerobic and aerobic exercise load tests (a 400-m race, 16 min on a treadmill, Bruce method, 13.5metabolic equivalents (METs)) (Fig. 67). In the hypouricemia patient, (a) exercise reduced creatinine clearance (Fig. 68), (b) FEUA increased 5h after the exercise load test (Fig. 69), (c) the urinary 8-isoprostane level increased slightly 6-25h after the exercise load test, although there were no marked differences compared with the control values (Fig. 70), and (d) the urinary NOx level increased 2 and 5h after the exercise load test (Fig. 71). Thus, we found that exercise reduced creatinine clearance in the renal hypouricemia patient with a history of ALPE, but there was no marked influence of oxidative stress. 

Fig. 70. Exercise loading and urinary 8-iso-prostane levels. There were no marked differences in the changes in urinary 8-isoprostane between a patient with a history of ALPE and the control...

B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD. Thorax 2003 58 294-298. 32. 

Oner-l5ridogan Y, Ko9ak H, Giirdol F, Ko ak T, Erol B (2004) Urine 8-isoprostane F2tilpha concentrations in patients with neurogenic bladder due to spintil cord injury. Clin Chim Acta 339 43 7... 

Ruef, J., M. Moser, C. Bode, W. Kiibler, and M.S. Runge. 2001. 4-Hydroxynonenal induces apoptosis, NF-KB-activation and formation of 8-isoprostane in vascular smooth muscle cells. Basic eseardiinCardi 96 143-50. 

Sahin et al. [12] Breast cancer Antioxidants MDAJ., 8-isoprostane], 8-OhdGJ, and Bcl-2], increased Bax], caspase 31 and caspase 9]... 

Incteased serum urea-N and creatinine, MDA production, 8-isoprostane levels... 

Barden, A, Beilin, LJ, Ritchie, J, Croft, KD, Walters, BN andMichaef CA (1996) Plasma and urinary 8-isoprostane as an indicator of lipid peroxidation in pieeclampsia and normal pregnancy. ClinSci (London), 91, 711-718. 

Montuschi, P, Ciabattoni, G, Paredi, P, Pantelidis, P, du Bois, RM, Kharitonov, SA and Barnes, PJ (1998) 8-isoprostane as biomarker of oxidative stress in interstitial lung diseases. Am J Respir Crit Care Med, 158, 1524—1527. 

Montuschi, P, Collins, J V, Ciabattoni, G, Lazzeri, N, Corradi, M, Kharitonov, S A and Barnes, PJ (2000a) Exhaled 8-isoprostane as in vivo biomarker of lung oxidative stress in patients with COPD and healthy smokers. Am J Respir Crit Care Med, 162, 1175-1177. 

Montuschi, P, Kharitonov, SA, Ciabattoni, G, Corradi, M, van Rensen, L, Geddes, DM, Hodson, ME and Bames, PJ (2000b) Exhaled 8-isoprostane as a new non-invasive biomarker of oxidative stress in cystic fibrosis. Thorax, 55, 205-209. 

Cayman Chemical, Ann Harbor, USA Prostaglandin E2,8-isoprostane, cysteinyl-leuko-triene, nitrotyrosine, CGRP, PPAR-gamma, sPLA2... 

Vanaudenaerde BM, Wuyts WA, Geudens N, et al. Macrohdes inhibit IL17-induced IL8 and 8-isoprostane release from human airway smooth muscle cells. Am J Transplant 2007 7 76-82. 

Allograft rejection, Post-transplant BOS FEVl increase. BAL neutrophilia and levels of IL-8, 8-isoprostane 62 12 Azithromycin reduced BOS frequency by 44% if given prophylactically 69, 70... 

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