Intravenous injection advantages

Nanomaterials have three main advantages in chug delivery because of their small size. First, they are highly useful for intravenous injection. Second, they can result in less... 

The primary objective of integration plot analysis is to analyze the data on influx of the test substrate from the circulating blood to the retina (i.e., blood-to-retina direction) across the BRB after intravenous administration of the test substrate. The advantage of this approach is that it allows reliable determination of the retinal uptake (i.e., clearance) of the test substrate which has a slow permeability across the BRB [28], On the other hand, due to the intravenous injection, interference by endogenous substrates and plasma-protein binding of the test substrate can produce an unseemingly low estimate of the retinal uptake. 

Several uses have been suggested for levulinic acid and its salts. Thus, calcium levulinate seems to have advantages as a calcium carrier in tuberculosis therapy, and it is said to be more suitable than calcium gluconate for intravenous injection. A mercury salt, phenyl mercury... 

Intramuscular injection offers the advantage of providing a relatively rapid effect (i.e., within a few minutes), while avoiding the sudden, large increase in plasma levels seen with intravenous injection. The... 

This method of measuring eosinophil accumulation in vivo has the advantage that it does not require the use of radioactive material. However, it is less sensitive to low doses of chemoattractant, although this can be overcome by the intravenous injection of IL-5 to boost the numbers of eosinophils in the circulation (7). The isolation of eosinophils, for use as a standard, and the preparations for intradermal injections have been described in Subheadings... 

Some authors recommend injecting 125 mg of solumedrol intravenously before starting a phenol peel injecting a steroid is said to reduce post-peel edema and to prevent some of the complications described above. However, I have not noticed any advantage from this injection. The aftereffects of the peel are similar with or without corticosteroids. However, it is worth considering an intravenous injection of prednisolone for patients who smoke and do not have any history of gastric ulcers. Smokers have an increased risk of laryngeal edema immediately after a full-face phenol peel. 

Review the advantages and disadvantages of oral administration and intravenous injection of drugs. 

Ans. The amines with medicinal properties generally show low solubility in water because they contain too many carbons. Conversion to the amine salt is advantageous for intravenous injection and also for absorption after oral administration since the amine salt is much more water-soluble. 

The structure of fentanyl and related compounds are given in Table 24.4. Fentanyl is a p agonist with approximately 80 times greater potency than morphine. Fentanyl has been used in combination with nitrous oxide for balanced anesthesia and in combination with droperidol for neurolepalgesia. The advantages of fentanyl over morphine for anesthetic procedures are its shorter duration of action (1-2 hours) and the fact that it does not cause histamine release on intravenous injection. 

The beneficial character of low toxicity may be described as the fourth advantage. Generally, polymeric siufactants are known to be less toxic than low molecular weight siufactants such as sodiiun dodecyl sulfate. In fact, some Plxmonic block copol3rmers [poly(propylene oxide)-poly(ethylene oxide)-poly-(propylene oxide)] have been approved for intravenous injection. Further information about Plxmonic block copolymers can be obtained in another chapter written by Bronich and Kabanov. 

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