Drug delivery intraocular

Describe the approaches used in intraocular drug delivery... [Pg.298]

Steffansen B, Ashton P, Buur A. Intraocular drug delivery. In vitro release studies of 5-Fluorouracil from N-l alkoxycarbonyl prodrugs in silicone oil. Int J Pharm 1996 132 243-250. [Pg.25]

Regulatory Issues Specific to Intraocular Drug Delivery... [Pg.66]

Several different intraocular drug delivery systems using biodegradable polymers such as microspheres (5-9), intraocular implants (10-13), scleral plugs (3,4,14-22), and intrascleral implants (23) have been developed. [Pg.177]

There is topographic variation in the density of scleral emissaries, with the temporal sclera being most free of these vascular conduits (20). The landscape of scleral thickness is quite varied. The mean thickness of human sclera is 0.53 mm at the limbus, 0.39 mm at the equator, and 0.9-1.0mm near the optic nerve (21). However, even these figures are subject to great variation, with equatorial thickness frequently below 0.1 mm. These factors would be important considerations in the placement of a transscleral drug delivery device. With a mean total surface area of 16.3 cm2, the sclera is an inviting portal for intraocular drug delivery. [Pg.194]

Ben-Nun J, Cooper RL, Cringle SJ, Constable IJ. A new method for continuous intraocular drug delivery. Aust N Z J Ophthalmol 1989 17 185-190. [Pg.224]

Spanning the most recent technologies in the field, this source covers current methods, clinical applications, and new delivery systems to treat and prevent proliferative eye disease...examines the factors that trigger and perpetuate intraocular wound healing in diseases such as proliferative vitreoretinopathy...reviews the results of clinical trials of new sustained delivery implants...and analyzes the potential of intraocular drug delivery for the treatment of posterior segment diseases. [Pg.367]

Intraocular drug delivery / edited by Glenn J. Jaffe, Paul Ashton, Andrew Pearson, p. cm. [Pg.372]

PEG-based copolyesters possess the ability to serve as absorbable controlled release carriers for a whole host of bioactive agents. The ability to provide a means of local therapy with systemically toxic agents directly at the site of interest has heightened awareness of these PEG-based systems. In addition, since these copolymers are absorbable, they allow for local drug delivery without the inherent risks associated with permanent foreign bodies. Some applications of the PEG-based systems include, but are not limited to, antibiotic formulations for osteomyelitis, controlled release of vaccines, intra-vaginal delivery of misoprostol, periodontal application of antibiotics, and intraocular drug delivery. [Pg.45]

M.H. Rahimy, G.A. Peyman, S.Y. Chin, R. Golshani, C. Aras, H. Borhani, H. Thompson, Polysulfone capillary fiber for intraocular drug delivery in vitro and in vivo evaluations, J. Drug Target. 2 (4) (1994) 2455-2480. [Pg.308]

Li PY, Shih J, Lo R, Saati S, Agrawal R, Hiunayun MS, Tai YC, Meng E (2008) An electrochemical intraocular drug delivery device. Sens Actuators A-Phys 143 41-48... [Pg.667]

N. Baziuk, C.M. Gremillion, Jr., G.A. Peymcui, cuid H. Cho, Collagen shields cuid intraocular drug delivery Concentration of gentcunicin in the aqueous and vitreous of a rabbit eye after lensectomy and vitrectomy, 7 L Ophthalmol, 16,101-107,1992. [Pg.478]

Palamoor, M., Jablonski, M.M. Synthesis, characterization and in vitro studies of celecoxib-loaded poly(ortho ester) nanoparticles targeted for intraocular drug delivery. CoUoids Surf. B Biointerfaces 112, 474 82 (2013). doi 10.1016/j.colsurfb.2013.07.039... [Pg.472]

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