Intraductal papillary mucinous tumor

The detection of telomerase activity or hTERT mRNA in excretion, secretion, brushings, and washings has been evaluated. In pancreatic, secretion samples, which contain freshly exfoliated cells, detection of telomerase activity was encouraging for cancer detection. Telomerase activity was also found to be useful in distinguishing between adenoma and carcinoma in intraductal papillary-mucinous tumors, which can sometimes be difficult to diagnose. In bronchial brushing samples, the clinical sensitivity of cancer detection is below 70% and false-positive results are commonly encountered because of contamination witli lymphocytes, which contain measurable telomerase activity. The measurement of telomerase is also expected to become a useful... 

Nagasaka T, Nakashima N. Problems in histological diagnosis of intraductal papillary-mucinous tumor (IPMT). Hepatogas-troenterology. 2001 48 972-976. 

Niijima M, Yamaguchi T, Ishihara T, et al. Immunohistochemical analysis and in situ hybridization of cyclooxygenase-2 expression in intraductal papillary-mucinous tumors of the pancreas. Cancer. 2002 94 1565-1573. 

Islam HK, Fujioka Y, Tomidokoro T, et al. Immunohistochemical analysis of expression of molecular biologic factors in intraductal papillary-mucinous tumors of pancreas—diagnostic and biologic significance. Hepatogastroenterology. 1999 46 2599-2605. 

Kawahira H, Kobayashi S, Kaneko K, et al. p53 protein expression in intraductal papillary mucinous tumors (IPMT) of the pancreas as an indicator of tumor malignancy. Hepatogastroenterology. 2000 47 973-977. 

Kitagawa Y, Unger TA, Taylor S, et al. Mucus is a predictor of better prognosis and survival in patients with intraductal papillary mucinous tumor of the pancreas. J Gastrointest Surg. 2003 7 12-18 discussion 18-19. 

Sasaki S, Yamamoto H, Kaneto H, et al. Differential roles of alterations of p53, pl6, and SMAD4 expression in the progression of intraductal papillary-mucinous tumors of the pancreas. Oncol Rep. 2003 10 21-25. 

Fukukura Y, Fujiyoshi F, Sasaki M, Inoue H, Yonezawa S, Na-kajo M (2000) Intraductal papillary mucinous tumors of the pancreas thin-section helical CT findings. AJR Am J Roentgenol 174 441-447... 

Irie H, Yoshimitsu K, Aibe H et al. (2004) Natural history of pancreatic intraductal papillary mucinous tumor of branch duct type follow-up study by magnetic resonance cholangiopancreatography. J Comput Assist Tomogr 28 117-122... 

Shibahara H, Tamada S, Goto M, et al. Pathologic features of mucin-producing bile duct tumors two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am J Surg Pathol. 2004 28 327-338. 

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