Intracellular proteins, coagulation

For instance, if ampules of aqueous products were to be sterilized in a hot air oven, the mechanisms of microbial inactivation would still be by coagulation of intracellular proteins. However, heat transfer from hot air is much slower than heat transfer from steam, which is why this is not seen as a practical process. Microwave irradiation could be an alternative means of sterilizing aqueous pharmaceutical products utilizing the same antimicrobial mechanisms as steam certainly there is evidence that microwave killing patterns are mainly due to heat transfer with very little direct energy being absorbed from the microwaves. 

Necrotic phase This phase occurs 1-4 days after injury. Cells die from coagulation of intracellular protein. Vascular thrombosis and bacterial invasion may worsen the underlying injury. The esophagus is especially vulnerable to perforation during this phase. 

Intracellular protein delivery is considered to be the most direct, fastest and safest approach for curing gene-deficiency diseases or disorders affecting primarily cellular processes, such as cystic fibrosis, coagulation disorders, otl-antitrypsin deficiency, immunoglobulin deficiencies, endocrine disorders and lysosomal storage diseases, where the expression of required proteins in the host cells is limited due to the defects in the required cellular (endogenous transcriptional) machinery/ ... 

In ischemic episodes such as occur in myocardial infarction, lack of oxygen forces cells to rely on anaerobic glycolysis, which increases production of lactic add The consequent intracellular acidosis can cause proteins to denature and precipitate, leading to coagulation necrosis. 

Astringents coagulate protein in skin and mucous membrane cells to form a superficial protective layer. By reducing the secretion of mucus and intracellular contents from damaged cells they help relieve local irritation and inflammation. 

It remains unclear whether such approaches are truly general, in particular for proteins such as receptors that span different cellular compartments. For example, some receptor tyrosine kinases contain a kringle domain in their extracellular regions. Would such protocols predict common functions for intracellular tyrosine kinases and extracellular kringle-containing proteins, such as those of the hlood coagulation pathway Nevertheless, it is apparent that considerable functional constraints exist for domains to co-occur and that domain combinations are often very limited. 

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