Interpolyelectrolyte complexes

LW Seymour, K Kataoka, AV Kabanov. In PF AV Kabanov, LW Seymour, eds. Interpolyelectrolyte Complexes for Gene Delivery. Chichester, UK WUey, 1998, pp 197-218. 

Interpolyelectrolyte complexes Micelles Nanostructures Polyelectrolytes Supramolecular chemistry... 

Interpolyelectrolyte complexation between various charged (co)polymers or between charged double-hydrophilic copolymers and surfactants has been used as a tool to generate well-defined micellar structures, as will be discussed in more detail in Sect. 7.4. 

Liu B, Bazan GC (2004) Interpolyelectrolyte complexes of conjugated copolymers and DNA platforms for multicolor biosensors. J Am Chem Soc 126 1942-1943... 

Kabanov, A.V., Kiselev, V.I., Chikindas, M.L., Astafieva, I.V., Glukhov, A.I., Gordeev, S.A., Izumrudov, V.A., Zezin, A.B., Levashov, A.V., Severin, E.S. and Kabanov, V.A. (1989) Increasing of transforming activity of plasmid DNA by incorporating it into an interpolyelectrolyte complex with a carbon chain polycation. Dokl. Akad. Nauk SSSR (in Russian), 306, 226-229. 

Kabanov, A.V., Szoka, F.C. and Seymour, L.W. (1998b) Interpolyelectrolyte complexes for gene delivery polymer aspects of transfection activity. In A. V.Kabanov, P.L.Felgner and L.W.Seymour (eds) Self-assembling Complexes for Gene Delivery. From Laboratory to Clinical Trial. Chichester, UK John Wiley Sons. pp. 197-218. 

Maruyama, A., Watanabe, H., Ferdous, A., Katoh, M, Ishihara, T. and Akaike, T. (1998) Characterization of interpolyelectrolyte complexes between double- stranded DNA and polylysine comb-type copolymers having hydrophilic side chains. Biocmjug. Chem., 9, 292-299. 

Sukhishvili, S.A., Obol skii, O.L., Astaf eva, I.V., Kabanov, A.V. and Yaroslavov, A.A. (1993) DNA-containing interpolyelectrolyte complexes interaction with liposomes. Polymer Sci. (translatedfrom Vysokomol. Soedin.), 35, 1602-1606. 

Moustahne RI, Zaharov IM, Kemenova VA. 2006. Physicochemical characterization and drug release properties of Eudragit E PO/Eudragitw L 100-55 interpolyelectrolyte complexes. Eur. J. Pharm. Biopharm. 63 26-36. 

Schwarz S, Dragan S (2004) Nonstoichiometric interpolyelectrolyte complexes as colloidal dispersions based on NaPAMPS and their interaction with colloidal sihca particles. Macromolecular Symposia 210(1) 185... 

By increasing the hydrophobicity of plasmids and reducing their net negative surface charge, PVP may facilitate the uptake of plasmids by muscle cells. Intramuscular injection of PVP-based plasmid formulations in rats significantly increased the number and distribution of expressing cells, as compared to unformulated plasmid. The formation of condensed interpolyelectrolyte complexes between PVP and DNA has been proposed to both protect DNA from nuclease degradation and facilitate its cellular uptake by hydrophobic interaction with cell membranes. The increased hydrophobicity of the complex may enhance interaction with cell membranes and facilitate cell uptake. 

Nanostructures primarily result from polyelectrolyte or interpolyelectrolyte complexes (PEC). The PEC (also referred to as symplex [23]) is formed by the electrostatic interaction of oppositely charged polyelectrolytes (PE) in solution. The formation of PEC is governed by physical and chemical characteristics of the precursors, the environment where they react, and the technique used to introduce the reactants. Thus, the strength and location of ionic sites, polymer chain rigidity and precursor geometries, pH, temperature, solvent type, ionic strength, mixing intensity and other controllable factors will affect the PEC product. Three different types of PEC have been prepared in water [40] (1) soluble PEC (2) colloidal PEC systems, and (3) two-phase systems of supernatant liquid and phase-separated PEC. These three systems are respectively characterized as ... 

Kabanov VA. Basic properties of soluble interpolyelectrolyte complexes applied to bioengineering and cell transformation. In Dubin P, Bock J, Davies RM, Schulz DN, Thies C, eds. Macromolecular Complexes in Chemistry and Biology. Berlin Springer Verlag, 1994 151-174. 

Bakeev KN, Izumrudov VA, Kuchanov SI, Zezin AB, Kabanov VA. Kinetics and mechanism of the macromolecular exchange in an interpolyelectrolytic complex. Doklad Akad Nauk SSSR 1988 300(1) 132-135. 

Buchhammer HM, Lunkwitz K, Pergushov DV. Salt effect on surface modification of silica by interpolyelectrolyte complexes. Macromol Symp 1997 126 157-171. 

Pergushov DV, Buchhammer HM, Lunkwitz K. Effect of a low-molecular-weight salt on colloidal dispersions of interpolyelectrolyte complexes. Colloid Polym Sci 1999 277 101-107. 

Brand F, Dautzenberg H. Structural analysis in interpolyelectrolyte complex formation of sodium poly(styrenesulfonate) and diallyldimethylammonium chloride-acrylamide copolymers by viscometry. Langmuir 1997 13(11) 2905-2910. 

Kuderbaigenov SE, Nurkeeva ZS, Sigitov VB, Akimbekova KZ, Ushanov VZ. Interpolyelectrolyte complexes of poly[4-(but-3-en-l-ynyl)-l-methylpiperi-din-4-ol] with poly(carboxylic acids). Macromol Chem Phys 1997 189 183— 191. 

Pergushov DV, Izumrudov VA, Zezin AB, Kabanov AV. Stability of interpolyelectrolyte complexes in aqueous saline solutions—effect of the degree of polymerization of polyions. Vysokomol Soedin 1995 37(10) 1739-1746. 

Richardson SCW, Pattrick NG, Man YKS, Ferruti P, Duncan R. Poly(amidoamine)s as potential non viral vectors Ability to form interpolyelectrolyte complexes and to mediate transfection in vitro. Biomacromolecules 2001 2 1023-1028. 

Moustafine, R.I. Bukhovets, A.V. Sitenkov, A.Y. Kemenova, V.A. Rombaut, R Van den Mooter, G. Eudragit E PO as a complementary material for designing oral drug delivery systems with controlled release properties Comparative evaluation of new interpolyelectrolyte complexes with countercharged Eudragit LlOO copolymers. Mol. Pharm. 2013,10 (7), 2630-2641. 

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