International Proprietary Name

The Rule-of-Five (Ro5) is one of the best known and widely accepted drug-likeness filters. The Ro5 was derived from an analysis of 2,245 drug candidates from World Drug Index (WDI) with assigned United States Adopted Name (USAN) or International Proprietary Name (INN) that are believed to have reached Phase II trials. It states that a compound violating any two of the following rules is likely to be poorly absorbed ... 

The USAN name is recognized as the official name bytheU.S. Food and Drug Administration. International Proprietary Names (INN) are generic names as designated by the World Health Organization. 

World Health Organization Drug Dictionary. A creation of the Uppsala Monitoring Centre in Sweden designed to take international, proprietary, and nonproprietary or generic drug names and classify them into common preferred terms. 

The recommended International Non-proprietary Name (rINN) is used throughout the book, except when the terms used are adrenaline and noradrenaline. For further reference, see the British National Formulary. 

Under Directive 2004/27/EC, there are various changes to the information to be included on the product label and certain provisions relating to the product s package leaflet. There is also a new requirement for the name of the medicinal product to be expressed in Braille format on the label. For products containing up to three active substances, the legislation specifies that the international non-proprietary name (INN) must also appear on the labelling. The MAH must also ensure that the package leaflet is made... 

When possible, we have attempted to indicate why fluoiination has been performed, according to the general statements described in the first part of this chapter. In some cases, we have included challenging aspects of syntheses. Concerning the marketed or advanced developed drugs, more references can be found in Chemical Abstracts, under INN names (International Non-proprietary Names). 

In order to give a clear overview, this chapter classically introduces pharmaceuticals according to their respective therapeutic class. Their chemical synthesis is given only when it has a specific interest in fluorine chemistry. The reader will appreciate the marketed names of the cited pharmaceuticals reported under INN names (International Non-proprietary Names) in the appendix. General references about marketed products (or under development) can be found in the Chemical Abstracts by using the INN (italic in the text). 

U.S. Adopted Name Indinavir Sulfate International Non-Proprietary Name Indinavir International Non-Proprietary Name modified Indinavir Sulfate (This nomenclature will be used throughout to designate the sulfate salt (ethanol solvate) unless otherwise indicated.)... 

Table 3 Recommended International Non-proprietary Names (rINNs) and chemical names of the major prostaglandins...

We are also currently experiencing a transitional period during which many established drug names are being changed to recommended international non-proprietary names (rINN) both names are included here, the rINN preceding the older name. 

World Health Organization, International non-proprietary names for pharmaceutical substances (INN) List 84, WHO Drug Inf, 14, 245-280, 2000. 

Drugs have usually been designated by their recommended or proposed International Non-proprietary Names (rINN or pINN) when these are not available, chemical names have been used. In some cases brand names have been used. 

International travellers with chronic illnesses will be grateful for recommended International Nonproprietary Names (above) as proprietary names often differ from country to country. The reasons are linguistic as well as commercial (see below). 

The generic name, the standard being the WHO International Non-proprietary Name, is the first choice of the EMBASE indexers and for combination preparations the brand name is preferred. However, EMBASE allows drugs to be indexed under numerous names, more so than MEDLINE, and even includes the name of the manufacturer if it is in the original article. EMBASE concentrates more on the pharmacological and toxicological aspects of the biomedical literature than MEDLINE. 

Although epinephrine is the recommended International Non-proprietary Name (rINN), there are good reasons why the name adrenahne should be preferred, based on usage, history, etymology, and, most importantly, risk of chnical errors (1). 

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