Ethanol solvates

To the crude product there was added 100 ml of ethanol with warming until a clear solution was obtained. Then 150 ml ethyl acetate was added and the resultant filtered through a glass mat and the filtrate adjusted to pH 1 by the addition of saturated ethanolic HCI. Crystallization soon occurred. The resultant was allowed to stand at 0°C for 18 hours and then filtered through a sintered glass mat. The solid was dried under vacuum at 60°C for 18 hours yielding 35 g, a 67% yield of 7(S)-chloro-7-deoxylincomycin hydrochloride as an ethanol solvate. 

C42H83NO9 0.5 C2HeO D-Dihydro-N-(2-D-hydroxyoctadecanoyl)-/ -D-galactosylsphingosine, ethanol solvate dihydrocerebroside, ethanol solvate (HCEREB)282... 

C21H42N5On+ I- H20 C2H60 Apramycin hydriodide, monohydrate, ethanol solvate APRAMI 43 372... 

C30H50NOj j+ Br 0.6 C2HeO Demycarosylleucomycin A-3 hydrobromide, ethanol solvate DMCLCM10 43 351... 

Methoxypurine was found to crystallize as a hemihydrate from /V,/V -dimethyl formamide, and as a trihydrate from water [63]. Thermal treatment of the trihydrate could be used to obtain the hemihydrate. Zafirlukast was obtained in the form of monohydrate, methanol, and ethanol solvatomorphs, with the drug substance adopting a similar conformation in all three structures [64], In the isostructural methanol and ethanol solvates, the solvent molecules are hydrogen-bonded to two zafirlukast molecules, while in the monohydrate, the water molecules are hydrogen-bonded to three zafirlukast molecules. The structures of the acetone and isopropanol solvatomorphs of brucine have been reported, where the solvent controlled the self-assembly of brucine on the basis of common donor-acceptor properties [65],... 

US patent 6,821,990, Ethanol solvate of (—)-cA-2-(2-chlorophenyl)-5,7-dihy-droxy-8 [4R-(3S-hydroxy-l-M ethyl) piperidinyl]-4H-l-benzopyran-4-one [118], Disclosed in this invention is an ethanol solvate of (—)-cA-2-(2-chlorophenyl)-5,7-dihydroxy-8[4R-(3S-hydroxy-l-methyl)piperid inyl]-4H-l-benzopyran-4-one hydrochloride (identified as Form II), a method of making Form II, and a composition comprising Form II. 

Bis(2-hydroperoxy-2,2-diphenylethyl)barbituric acid ethanol solvate (EACJIB) 1.450 1.446 102.1 92... 

U.S. Adopted Name Indinavir Sulfate International Non-Proprietary Name Indinavir International Non-Proprietary Name modified Indinavir Sulfate (This nomenclature will be used throughout to designate the sulfate salt (ethanol solvate) unless otherwise indicated.)... 

Free base C3(,H47N504 Sulfate Salt C36H47N5O4 H2SO4 Ethanol Solvate C36H47N5O4 H2SO4 CNHjOH... 

Free base 613.80 Sulfate Salt 711.88 Ethanol Solvate 757.94... 

Crystallographic quality ciystals of indinavir sulfate salt were grown hy slow diffusion of methanol into an ethanol/water solution. As confirmed by TG/IR results, the crystals obtained were a mixed mono-methanol / mono-ethanol solvate. The compound crystallized in the P2, space group, (monoclinic crystal system) with 2 molecules per unit cell. The cell constants were found to be a= 14.321(1)A, 6 = 10.091(1)A, c = 15.192(1)A, P = 95.50(1)°, andV=2185.5A. The calculated density was 1.200 g/cm. A view of the crystallographic unit cell packing is shown in Figure 4, with the solvent molecules omitted [7]. 

Finally, in the crystal structures of the chloroform and ethanol solvates of [(dppmSe)2Au]Cl [91] the ions are connected into chains by C-H - Cl hydrogen bonds, whereby the chloride accepts two hydrogen bonds. Additionally, there is a C-H - Cl contact from a solvent molecule in the chloroform solvate (Figure 5.56b) and an O- Cl contact involving the solvent in the ethanol solvate. 

Thermal analysis (TGA and DSC) of spironolactone and its ethanol, methanol, acetonitrile, ethyl acetate, and benzene solvates has been used to characterize the materials [61]. The analysis was carried out under dry nitrogen ( 50 mL/min), with the samples being contained in aluminum sample pans. Thermograms were obtained at a heating rate of 10°C/minute, with the final temperature being 230°C. Spironolactone and its methanol and ethanol solvates exhibited small exothermic transitions in addition to the anticipated endotherms. 

Axillarine (40) was isolated from C. axillaris Ait. by Crout.20 The crystal structure of the ethanol solvate of axillarine hydrobromide has been determined by X-ray diffraction methods.21 The absolute configurations of the four chiral centres in the necic acid portion have been established. The overall shape of axillarine is somewhat similar to fulvine (41),22 which also has an 11-membered macrocyclic... 

Obviously, the 5-methyl substituent sterically impedes the ethanol solvation of the NH form (25a), thus favouring reaction at the more exposed 4-amino group. In water, protonation of the ring nitrogen atom and solvation of the resulting NH form (25a) by the smaller water molecules can take place despite the methyl group [172],... 

The crystal structure of a single stabilized nitronate carbanion derived fn n phenylnitromethane is reported as the polymeric ethanol solvate (185). The same geometry found in the nitronate anion (185) was also found for the r-butyldimethylsilyl ester derived fiom quenching this nitronate. References to other structures containing carbanions stabilized by a nitro group are given in Table 3 however, it is to be noted that these are derived fiom highly acidic carbon acids. 

C,6H44Bi2O0.5C2H6O Bis[bis(2,4,6-trimethylphenyl)bismuthyl] oxide ethanol solvate 6.5-28 ... 

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