International Fragrance Association

Health and Safety. This material has a Generally Recognized As Safe (GRAS) status indicated by the Flavor and Extract Manufacturers Association for use in flavors and by the Council of Europe for use as a flavor. Benzyl alcohol satisfies the most current guidelines published by (lie International Fragrance Association (IFRA) which governs the use of fragrance materials. 

This chapter will look at the composition of a number of popular aromatherapy materials. There is a lot of published data describing chemical compositions. This can be found in varying degrees of complexity in the aromatherapy books and, additionally, from a number of bodies such as ISO (International Organization for Standardization), RIFM (Research Institute for Fragrance Materials), IFRA (International Fragrance Association), AFNOR (Association Franchise de Normalisation) and the BP (British Pharmacopoeia). 

Cinammic aldehyde (cinnamaldehyde) is also a powerful skin sensitizer and the International Fragrance Association recommends its use with equal amounts of d-limonene as a quencher (see page 65). 

The organizations encountered when examining the composition of essential oils include the Research Institute for Fragrance Materials (RIFM), the International Fragrance Association (IFRA), the International Organization for Standardization (ISO), the Association Francaise de Normalisation (AFNOR) and the British Pharmacopoeia (BP). There is some overlap between recommendations for usage and safety by these bodies. The background and roles of RIFM and IFRA are described in the next chapter in relation to safety. 

Restrictions on the use of a given ingredient are identified. Restrictions are set out in the Directive itself or in the IFRA (International Fragrance Association) code of practice. These restrictions may take the form of a quantitative limitation (expressed as a percentage of the final product or as a concentration for application to the skin), or the ingredient may have to meet certain specifications or may only be used in conjunction with certain specified ingredients. These substances are marked with one asterisk for IFRA restrictions or with two asterisks for restrictions in the Cosmetic Products Directive. 

House of Lords Report on Complementary and Alternative Medicine u7ww.publicati0ns.parliament.uk/pa/ld/ldsctech.htm IFR A - International Fragrance Association http /fwww.infraorg/About/lfra.asp... 

IFRA International Fragrance Association. An advisory body for safety of materials. 

The overall RIFM process results in well-documented conclusions that are provided to the International Fragrance Association (IFRA) as the basis... 

See also International Fragrance Association (IFRA) Limonene Research Institute for Fragrance Materials (RIFM). 

See also Flavor and Extract Manufacturers Association Food Additives Food and Drug Administration, US International Fragrance Association (IFRA) Joint FAO/ WHO Expert Meetings (JECFA and JMPR) Research Institute for Fragrance Materials (RIFM). 

Low levels of D-limonene in the diet have not been reported to cause adverse effects in humans. D-Limonene can be a dermal sensitizer (see above for discussion about D-limonene oxidation products) however, an 8% solution of D-limonene in petrolatum did not cause an allergic skin response in any of 25 volunteers tested. D-limonene is also a recommended quencher in that it can decrease the sensitizing effect of cinnamic aldehyde when used at a 1 1 ratio with cinnamic aldehyde (International Fragrance Association, that is, IFRA, guidelines developed and used by the fragrance and consumer product industries). There is inadequate evidence in humans for the carcinogenicity of D-limonene, and the overall conclusion by experts is that, as discussed above, D-limonene produces renal tubular tumors in male rats by a non-DNA reactive a-2-globulin-asso-ciated response. Therefore, the mechanism by which D-limonene increased the incidence of renal tubular tumors in male rats is not relevant to humans. 

See also Carcinogen Classification Schemes Carcinogenesis Fragrances and Perfumes International Fragrance Association (IFFiA) Risk Assessment, Human Health Toxicity Testing, Sensitization. 

The International Fragrance Association (IFRA) was founded in 1973, in Geneva, to represent the collective interests of the fragrance industry worldwide. IFRA is a Swiss association with a Belgian branch. 

International Fragrance Association 49, Square Marie-Louise B-1000 Brussels Belgium... 

Tel. +32-2-238-9904 International Fragrance Association 5, Chemin de la Parfumerie CH-1214 Vernier Geneva Switzerland... 

All scientific efforts are reviewed by an independent experts panel of academic dermatologists, toxicologists, and environmental scientists. The experts panel uses a decision tree approach to assessing the dermal, systemic, and environmental endpoints. Conclusions of the expert panel on safe use, drawn from critical evaluation of all available hazard data, and exposure information provided by industry, form the basis for standards issued by the International Fragrance Association. 

Appendix 1.23 International Fragrance Association (IFRA), Pages 524-525, Audrey Martin... 

The availability of basic ingredients and their prices no doubt decide about the size of business. Most of the big multinational companies are no doubt active in most of the important cities in the world, either they have manufacturing bases or offices. For example, major players that are active in aroma chemicals have built their factories in various parts of the world in order to meet the local demands. Today the fragrance business worldwide is represented by the International Fragrance Association (IFRA) which was originally comprised of 14 member countries (Table 10.3). 

Institut Superieur Internacional du Parfum, de la Cosmetique et de FAroma-tique Alimentaire, 36 Rue du Parc de Clagny, 78000 Versailles, France International Federation of Cosmetic Societies, Delaporte House, 57 Guildford Street, Luton, Bedfordshire LU1 2NL, UK International Fragrance Association (IFRA), 8 Rue Charles Humbert, CH 1025 Geneva, Switzerland... 

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