Integrins transmembrane

Miyamoto, S. Akiymam, S.K. and Yamada, K.M. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function (1995) Science 267, 883-885... 

Luo BH, Springer TA, Takagi J. A specific interface between integrin transmembrane helices and affinity for ligand. PLoS. Biol. 2004 2 el53. 

Luo BH, Carman CV, Takagi J, Springer TA. Disrupting integrin transmembrane domain heterodimerization increases ligand binding affinity, not valency or clustering. Proc. Natl. Acad. Sci. U.S.A. 2005 102 3679-3684. 

Lau TL, Kim C, Ginsberg MH, Ulmer TS (2009) The structure of the integrin alphallbbeta3 transmembrane complex explains integrin transmembrane signalling. EMBO J 28 1351-1361... 

Integrins Transmembrane a)S-heterodimer a 165 kDa j , 90-120 kDa Plasmalemma Binding to laminins, fibronectin, collagen specificity depends on a)S composition Maintenance of cell to basement membrane and extracellular matrix binding... 

Yamada, K.M. and Miyamoto, S., Integrin transmembrane signaling and cytoskeletal control, Curr. Opin. Cell Biol. 7,681,1995. 

Integrins constitute a large family of a (3 heterodimeric cell surface, transmembrane proteins that interact with a large number of extracellular matrix components through a metal ion-dependent interaction. The term integrin reflects their function in integrating cell adhesion and migration with the cystoskeleton. 

Fibronectin receptor is a two-chain glycoprotein of the integrin family that serves as a transmembrane linker by binding to talin on the cytoplasmic side and to fibronectin on the external side of the membrane. The pull exerted by stress fibers on attached structures may be produced by bipolar assemblies of nonmuscle myosin molecules producing a sliding of actin filaments of opposite polarity. 

A family of transmembrane proteins referred to as integrins is capable of interactions with extracellular ligands as well as with the cytoskeleton. These have been implicated in cell-to-cell interactions through the extracel-... 

Cadherins Transmembrane glycoproteins (352) promoting cellcell adhesion (353,354) linked to integrins (355) and via catenins to muscle action (356)... 

Several families of integral proteins in the plasma membrane provide specific points of attachment between cells, or between a cell and extracellular matrix proteins. Integrins are heterodimeric proteins (two unlike subunits, a and /3) anchored to the plasma membrane by a single hydrophobic transmembrane helix in each subunit (Fig. 11-22 see also Fig. 7-30). The large extracellular domains of the a and /3 subunits combine to form a specific binding site for extracellular proteins... 

Integrins are transmembrane proteins of the plasma membrane that act both to attach cells... 

Other cell adhesion molecules. Long before the discovery of integrins another class of transmembrane adhesion molecules were recognized as members of the immunoglobulin family. These were called cell... 

The integrins (see also p. 405) comprise a large family of adhesive receptors that are found in animals from sponges to humans.63-65 They have both adhesive and signaling functions. Both subunits of their aP heterodimeric structures64 have single transmembrane... 

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