Integrins receptor

GPIIb/IIIa Integrin Receptor Antagonists In the Rapid Diagnosis of Thromboembolic Events... 

Figure 48-3. Schematic representation of fibronectin. Seven functional domains of fibronectin are represented two different types of domain for heparin, cell-binding, and fibrin are shown. The domains are composed of various combinations of three structural motifs (I, II, and III), not depicted in the figure. Also not shown is the fact that fibronectin is a dimer joined by disulfide bridges near the carboxyl terminals of the monomers. The approximate location of the RGD sequence of fibronectin, which interacts with a variety of fibronectin integrin receptors on cell surfaces, is indicated by the arrow. (Redrawn after Yamada KM Adhesive recognition sequences.

Figure 48-4. Schematic representation of a cell interacting through various integrin receptors with collagen, fibronectin, and laminin present in the ECM. (Specific subunits are not indicated.) (Redrawn after Yamada KM Adhesive recognition sequences. J Biol Chem 1991 266 12809.)...

Baiillari G, Gendelman R, Gallo RC, Ensoli B (1993) The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the ROD amino acid sequence. Proc Natl Acad Sci USA 90(17) 7941-7945... 

In the intact blood vessel, ligands involved in adhesion to platelets, such as collagen, fibronectin, and von Willebrand factor, are sequestered in the subendothelium, thus preventing access to platelet adhesive receptors. Table 1 summarizes the functions of platelet membrane integrin receptors. 

Integrin receptor family Ligand recognized Result... 

G-Protein-Coupled/Integrin Receptors Receptor/Nonreceptor Kinases/Phosphatases Transcription Factors/Proteases... 

Park SI, Renil M, Vikstrom B et al (2002) The use of one-bead one-compound combinatorial library method to identify peptide ligands for cz4f31 integrin receptor in non-Hodgkin s lymphoma. Lett Pept Sci 8 171-178... 

Gudz, T. I., Schneider, T. E., Haas, T. A. et al. Myelin proteolipid protein forms a complex with integrins and may participate in integrin receptor signaling in oligodendrocytes. /. Neurosci. 22,7398-7407, 2002. 

Isberg, R. R., Hamburger, Z., and Dersch, P. (2000). Signaling and invasion-promoted uptake via integrin receptors. Microbes Infect. 2, 793-801. 

Integrin receptor-binding peptides have been used to enhance liposome binding, uptake, and expression (25,47 9). The inclusion of an 0(5pi integrin-targeted peptide into a liposomal complex enhanced transfection efficiency four- to five-fold in Jurkat cells and 10- to 13-fold in TF-1 cells (48). Confocal and electron microscopy revealed that the mechanism of cell entry conferred by RGD peptides on liposomes is predominantly by clathrin-coated endocytosis rather than by phagocytosis (50). 

Christofidou-Solomidou M, Bridges M, Murphy GF. Expression and function of endothelial cell alpha v integrin receptors in wound-induced human angiogenesis in human skin/SClD mice chimeras. Am J Pathol 1997 151(4) 975-983. 

VAPG Elastin Non-integrin receptor Vascular smooth muscle cells... 

KRSR Part of the heparin binding domain Non-integrin receptor Osteoblasts... 

FIGURE 9.6 Structure features of integrin receptors. Peptides or proteins containing the tripeptide sequence of RGD are recognized by several integrins present in the tumor cells. However, the protein tails pass through the plasma membrane with the hydrophobic domains and are locked into place. (From dos Santos, 2005)... 

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