Integrin targeting

Boturyn D, Coll J-L, Garanger E et al (2004) Template assembled cyclopeptides as multimeric system for integrin targeting and endocytosis. J Am Chem Soc 126 5730-5739... 

The neoangiogenic tumor vasculature overexpresses certain integrins and other surface markers, which can also be used for targeting of polyplexes. The RGD peptide motif has been successfully applied for integrin-targeted pDNA [125-128] and siRNA [129, 130] delivery. In many cases, the PEG motif-containing peptide was attached to the polycation via a PEG spacer. For RGD-PEG-PEI/pDNA polyplexes, an optimum grafting with RGD-PEG was required because transfection... 

Integrin receptor-binding peptides have been used to enhance liposome binding, uptake, and expression (25,47 9). The inclusion of an 0(5pi integrin-targeted peptide into a liposomal complex enhanced transfection efficiency four- to five-fold in Jurkat cells and 10- to 13-fold in TF-1 cells (48). Confocal and electron microscopy revealed that the mechanism of cell entry conferred by RGD peptides on liposomes is predominantly by clathrin-coated endocytosis rather than by phagocytosis (50). 

Hart SL, Arancibia-Carcamo CV, Wolfert MA, et al. Lipid-mediated enhancement of transfection by a nonviral integrin-targeting vector. Hum Gene Ther... 

RGD- Doxorubicin Peptide avp3 integrin/Targeting angiogenic vascnlature [79]... 

PLAEIDGIELTY Peptide a9pi integrin/Targeting Inng epithelia (cystic fibrosis) [112]... 

Collins, L., Sawyer, G.J., Zhang, X.-H., Gustafsson, K. and Fabre, J.W. (2000) In vitro investigation of factors important for the delivery of an integrin-targeted nonviral DNA vector in organ transplantation. Transplantation, 69, 1168-1176. 

Immunostimulation, 469 Importin-mediated nuclear import, 231 Inducible gene expression, 15 Integrin targeting, 349 Intramuscular gene delivery, 285 Ischemic heart disease (IHD), 500 Intravascular delivery, 489 Interstitial transport, 434 Intratumoral infusion, 436 Intion, 2... 

K. Kasono, J. L. Blackwell, J. T. Douglas, I. Dmitriev, T. V. Strong, P. Reynolds, D. A. Kropf, W. R. Carroll, G. E. Peters, R. P. Bucy, D. T. Curiel, and V. Krasnykh, Selective gene delivery to head and neck cancer cells via an integrin targeted adenoviral vector, Clin. Cancer Res. 5 2571 (1999). 

Winter PM, Neubauer AM, Caruthers SD, et al. Endothelial alpha beta 3 integrin-targeted fumagellin nanoparticles inhibit angiogenesis in atherosclerosis. Arterioscler Thromb Vase Biol 2006 26(9) 2103-9. 

Scott ES, Wiseman JW, Evans MJ, Colledge WH. Enhanced gene delivery to human airway epithelial cells using an integrin-targeting lipoplex. J Gene Med 2001, 3, 125-134. 

Angiogenesis is also a critical feature in the development of atherosclerotic plaques which, after rapture, can lead to myocardial infarction and stroke. Thus, the same a fSi integrin-targeted paramagnetic nanoparticles could be applied to detect atherosclerosis in rabbits [73]. Fibrin is another important target that is associated with... 

Kunath K, et al. (2003). Integrin targeting using RGD-PEI conjugates for in vitro gene transfer. J. Gene Med. 5 588-599. 

P.M. Winter, A.M. Neubauer, S.D. Caruthers, et al.. Endothelial a(33 integrin-targeted fumagillin nanoparticles inhibit angiogenesis in atherosclerosis, Arterioscler. Thromb. Vase. Biol. 26 (9) (2006) 2103-2109. 

Kotamraj, R, Rnssn, W. A., Jasti, B., Wu, J., Li, X. (2011). Novel integrin-targeted binding-triggered dmg delivery system for methotrexate. Pharmaceutical Research, 28(12), 3208-3219. 

Winter, P.M., Morawski, A.M., Caruthers, S.D., Fuhrhop, R.W. and Wickline, S.A. (2003) Molecular imaging of angiogenesis in early-stage atherosclerosis with alpha(v)beta3-integrin-targeted nanoparticles. Circulation, 108, 2270-4. 

Ito T., M. Inoue, K. Akamatsu, E. Kusaka, K. Tanabe, S. Nisbimoto. alpha(v)beta(3)-Integrin-targeting lantbanide complex Synthesis and evaluation as a tumor-homing luminescent probe, Bioorg. Med. Chem. Lett., 21, 3515D3518 (2011). 

Kasono K, Blackwell JL, Douglas JT, Dmitriev 1, Strong TV, Reynolds P, Kropf DA, Carroll WR, Peters GE, Bucy RP, Curiel DT, Krasnykh V. Selective gene deliveiy to head and neck cancer cells via an integrin targeted adenoviral vector. Clin Cancer Res 1999 5 2571-2579. 

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