Integrins glycosylation

Janik, M.E., Litynska, A., Vereecken, R Cell migration—the role of integrin glycosylation. Biochim. Biophys. Acta 1800, 545-555 (2010)... 

Shakoori AR. Phosphorylation and glycosylation interplay Protein modifications at hydroxy amino acids and prediction of signaling functions of the human beta(3) integrin family. J. Cell Biochem. 2006 99 706-718. 41. 

Sujan, A. H., Manilla, G. A., Skinner, M. (2003). Gel electrophoresis and mass spectrometric analysis of pi integrin to identify occupied N-linked glycosylation sites. Glycobiology, 13, 861. 

Finally, talin has also been reported to be modified by O-GIcNAc [73]. This important cytosolic protein appears to provide a bridge between the cytoplasmic domain of integrins and the cytoskeleton by interaction with another cytosolic protein, vinculin. Interestingly, non-glycosylated talin derived from platelets does not interact with vinculin, suggesting that 0-GlcNAc may be necessary for the interaction of these cytoskeletal components [73]. 

The evidence is increasing that glycosylation of integrins plays important modulatory roles in the function of these molecules. In other studies it appears that the glycosylation of at least one extracellular matrix glycoprotein, namely laminin, is important in cellular adhesion mediated by integrins. So far most information on the role of carbohydrates in integrin-mediated adhesive interactions has been obtained for the fibronectin receptors... 

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