Integration platform

If it is decided that an operation does require to be manned, then it may need to be manned on a 24-hour basis, or a 12-hour basis, or only for daily inspection. Accommodation may be provided on a separate living quarters platform or as part of an integrated platform, or on a floating hotel. 

The integration of more sophisticate simulation systems like virtual reality systems is also possible. Electronic data management systems, that provide an integration platform for both the layout and the material-flow based data models, give an important contribution to the whole planning process. 

D. E. Stafford and G. Stephanopoulus, Metabolic engineering as an integrating platform for strain development,... 

Ghosh S, Matsuoka Y, Asai Y et al (2011) Software for systems biology from tools to integrated platforms. Nat Rev Genet 12 821-832... 

InterProScan - an integration platform for the signature - recognition methods in InterPro. Bioinformatics 17, 847-848. 

GlycanBuilder/ WWW. dkfz-heidelberg. de/spec/ An integrated platform to build glycan structures. 

Li Q, Liu Z, Monroe H, Culiat CT. Integrated platform for detection of DNA sequence variants using capillary array electrophoresis. Electrophoresis 2002 23 1499-511. 

Sources for specific omics studies are also available. For instance, tools such as the RNA-Seq Atlas [17], Human Protein Atlas (HPA) [18], and the Human Metabolome Database (HMDB) [19] are useful for systemic genomic, proteomic, and metabolo-mics studies of human beings. LIPID Metabolites and Pathways Strategy (LIPID MAPS) [20] is a lipidomics gateway, an integrative platform for studies in lipid biology. More resources and updated links can be found at the Biomarkers portal (see Table 1). 

The development of a Polyamide-6 (Nylon 6) production process as described in Sect. 1.2 is employed to illustrate the issues discussed in the previous subsection. Besides being a process of industrial relevance, it has certain properties which stress the importance of a neutral model integration platform. First, the behavior of polymer materials is more difficult to describe than that of ordinary fluids which are handled quite well by most state-of-the-art simulation packages. Further, non-standard pieces of equipment are used to realize the Polyamide-6 process in a technically and economically efficient manner. In addition, the complete process is supposed to be analyzed including the downstream extrusion of the material. This extrusion step is not only required to formulate the polymer product into a particulate material, but it also could... 

These concepts are implemented in the integration platform CHEOPS Component-Based Hierarchical Explorative Open Process Simulator) [252, 409, 462]. The platform provides generic component prototypes and interfaces for the integration of models, solvers, and tools. The generic components are instantiated at run-time by concrete software components and classes representing actual unit operation models, solvers, etc. That way, arbitrary components from the list of available components can be used in the simulation. The list of model and solver components can easily be extended with the components that comply with the abstract structure and interface definitions. 

While being tailored to support Comos PT and development processes in chemical engineering, a mandatory requirement for the integrator platform is its adaptability to different tools and other application domains. 

The rest of this section is structured as follows In Subsect. 7.6.2, some of our past and current cooperations with different industrial partners are described. Subsect. 7.6.3 gives an overview of the system to be realized in the transfer subproject. In Subsect. 7.6.4, selected research activities needed for the realization of the Comos PT integrator platform are described in more detail. Subsect. 7.6.5 concludes this section. 

The integrator platform is intended to be used for Comos PT related data integration, e.g. for keeping simulation models and process flow diagrams consistent. This comprises internal data as well as external data sources. The integrator platform has to fulfill all requirements on integration tools as proposed in Subsect. 3.2.1. The key requirements are ... 

The integrator platform has to be tightly integrated with the Comos PT environment from the users perspective. Nevertheless, it must be easily adaptable to other tools and other domain.s of applications. 

Hoon, S., Smith, A. M., Wallace, 1. M., et al. (2008). An integrated platform of genomic assays reveals small-molecule bioactivities. Nat. Chem. Biol., 4, 498-506. 

Integrated Platforms for Gene, Promoter, and Splice Site Prediction Webgene http / / www. itba. mi. cnr.it/ webgene/... 

Two tools have recently been developed that offer to make the process of polymorphism analysis a lithe easier. PupaSNP and FastSNP are both integrated platform applications that will analyze all known (in the case of PupaSNP, also user submitted) polymorphisms in a given gene or list of genes. This feature obviously offers great benefits to the user in terms of speed and convenience, and as a first-pass analysis these tools both do a fine job however, it is worth taking some time to fully explore all avenues of analysis to add to the output of these tools. 

Davies TG, van Montfort RLM, Williams G, Jhoti H (2006) Pyramid an integrated platform for fragment-based drug discovery. In Jahnke W, Erlanson DA (eds) Fragment-based approaches in drug discovery. Wiley-VCH, Weinheim, p 193... 

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