Insulin-like growth binding protein

IGFBP-3 insulin-like growth factor binding protein 3... 

There is only one major system of interacting growth factors and receptors in the fetus — the insulin (INS) and insulin-like growth factor (IGF) system (Table 1 and Fig. 1). Ignoring various binding proteins that modulate IGF actions in tissues and... 

Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J 2000 HI 9 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein. J Biol Chem... 

Clemmons, D. R., W. H. Busby, T. Arai et al. 1995. Role of insulin-like growth factor binding proteins in the control of IGF actions. Prog Growth Factor Res 6(2-4) 357-366. 

Giovannucci, E. 1999a. Insulin-like growth factor-I and binding protein-3 and risk of cancer. Horm Res 51 Suppl 3 34-41. 

Holmes, M. D., M. N. Poliak, W. C. Willett, and S. E. Hankinson. 2002. Dietary correlates of plasma insulinlike growth factor I and insulin-like growth factor binding protein 3 concentrations. Cancer Epidemiol Biomarkers Prev 11 (9) 852—861. 

Karas, M., M. Danilenko, D. Fishman et al. 1997. Membrane-associated insulin-like growth factor-binding protein-3 inhibits insulin-like growth factor-I-induced insulin-like growth factor-I receptor signaling in ishikawa endometrial cancer cells. J Biol Chem 272(26) 16514—16520. 

Liu, C., F. Lian, D. E. Smith, R. M. Russell, and X. D. Wang. 2003. Lycopene supplementation inhibits lung squamous metaplasia and induces apoptosis via up-regulating insulin-like growth factor-binding protein 3 in cigarette smoke-exposed ferrets. Cancer Res 63(12) 3138-3144. 

Vrieling, A., D. W. Voskuil, J. M. Bonfrer et al. 2007. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am J Clin Nutr 86(5) 1456-1462. 

Graydon, R, SE Gilchrist, IS Young, U Obermuller-Jevic, O Hasselwander, and JV Woodside. 2007. Effect of lycopene supplementation on insulin-like growth factor-1 and insulin-like growth factor binding protein-3 a double-blind, placebo-controlled trial. EurJ Clin Nutr 61(10) 1196-2000. 

Kanagaraj, P, MR Vijayababu, B Ravisankar, J Anbalagan, MM Aruldhas, and J Aranakaran. 2007. Effect of lycopene on insulin-like growth factor-1, IGF binding protein-3, and IGF type-1 receptor in prostate cancer cells. 7 Cancer Res Clin Oncol 133 351-359. 

Li, L, H Ya, F Schumacher, G Casey, and JS Witte. 2003. Relations of serum insulin-like growth factor-1-(IGF-1) and IGF binding protein-3 to risk of prostate cancer(United States). Cancer Causes Control 14 721-726. 

Miyata, Y, H Sakai, T Hayashi, and H Kanetake. 2003. Serum insulin-like growth factor binding protein-3/ prostate-specific antigen ratio is a useful predictive marker in patients with advanced prostate cancer. Prostate 54 125-132. 

Horney, M.J. et al. (2001) Synthesis and characterization of insulin-like growth factor (IGF)-l photoprobes selective for the IgG-binding proteins (IGFBPs) photoaffinity labeling of the IGF-binding domain on IGFBP-2./. Biol. Chem. 276(4), 2880-2889. 

The presence of serum-binding proteins. Some biopharmaceuticals (including insulin-like growth factor (IGF), GH and certain cytokines) are notable in that the blood contains proteins that specifically bind them. Such binding proteins can function naturally as transporters or activators, and binding can affect characteristics such as serum elimination rates. 

Furstenberger, G. and Senn, H. 2002. Insulin like growth factors and cancer. Lancet Oncology, 3(5), 298-302. Kostecka, Z. and Blahovec, J. 2002. Animal insulin-like growth factor binding proteins and their biological functions. Veterinami Medicina 47(2-3), 75-84. 

Kleinman D, Karas M, Danilenko M (1996) Stimulation of endometrial cancer cell growth by tamoxifen is associated with increased insulin-like growth factor (IGF)-I induced tyrosine phosphorylation and reduction of IGF binding proteins. Endocrinology 137 1089-1095... 

Huynh H, Poliak M (1994) Uterotrophic actions of estradiol and tamoxifen are associated with inhibition of uterine insulin-like growth factor binding protein 3 gene expression. Cancer Res 54(12) 3115—3119... 

Hembree JR, Agarwal C, Beard RL, Chandraratna RA, and Eckert R [1996] Retinoid X receptor-specific retinoids inhibit the ability of retinoic acid receptor-specific retinoids to increase the level of insulin-like growth factor binding protein-3 in human ectocervical epithelial cells. Cancer Res 56 1794-1799... 

Hembree JR, Lambert A, Agarwal C, Efimova T, and Eckert RL [1999] Insulin-like growth factor binding protein-3 does not mediate the interferon-dependent... 

Human growth hormone (hGH) is a polypeptide with 191 amino acids. It is secreted by the pituitary gland. This hormone stimulates the production of insulin-like growth factor-1 (IGF-1) from the liver. Most of the positive effects of hGH are mediated by the IGF-1 system, which also includes specific binding proteins. 

Guan J, WiUiams CE, Skinner SJ, Mallard EC, Gluckman PD. 1996. The effects of insulin-like growth factor (IGF)-l, IGF-2, and des-IGF-1 on neuronal loss after hypoxic-ischemic brain injury in adult rats evidence for a role for IGE binding proteins. Endocrinology 137 893-898. 

Jones J, Clemmons D. 1995. Insulin-like growth factors and their binding proteins biological actions. Endo Rev 16 3-34. 

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