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Insulin Calcium-channel blockers

INSULIN CALCIUM CHANNEL BLOCKERS -DILTIAZEM, NIFEDIPINE Single case reports of impaired glucose intolerance requiring t insulin requirements with diltiazem and nifedipine Uncertain at present Evidence suggests that calcium channel blockers are safe in diabetics monitor blood glucose levels when starting calcium channel blockers... [Pg.412]

Calcium channel blockers minimally interfere with stimulus-secretion coupling in glands and nerve endings because of differences between calcium channel type and sensitivity in different tissues. Verapamil has been shown to inhibit insulin release in humans, but the dosages required are greater than those used in management of angina. [Pg.262]

Glucagon has also been used to stimulate insulin and C-peptide secretion, to see whether the islets still produce insulin, as a stimulatory test during pheochromocytoma, hyperinsulinism, and Zollinger-Ellison syndrome, or as an additive in upper gastrointestinal X-ray investigations (0.5-1 mg). It has been used in myocardial infarction, although its inotropic effects may present a risk. It has also been used to treat overdoses with beta-blockers (3) and calcium channel blockers (4), although its efficacy in such cases has only been demonstrated in animals (5) and to treat overdose with tricyclic antidepressants (6,7). [Pg.384]

Collings WCJ, Cullen MJ, Feely J. The effect of therapy with dihydropyridine calcium channel blockers on glucose tolerance in non-insulin dependent diabetes. Br J Clin Pharmacol 1986 21 568. [Pg.664]

Tolins JP, Raij L (1990) Comparison of converting enzyme inhibitor and calcium channel blocker in hypertensive glomerular injury. Hypertension 10 452-461 Tonshoff B, Powell DR, Zhao D et al. (1997) Decreased hepatic insulin-like growth factor (IGF)-I and increased IGF binding protein-1 and -2 gene expression in experimental uremia. Endocrinology 138 938-946... [Pg.128]

Calcium transport is essential for insulin secretion, which is therefore inhibited by calcium channel blockers (73). [Pg.600]

Current concepts of resuscitation after local anesthetic cardiotoxicity have been reviewed (17). Vasopressin may be a logical vasopressor in the setting of hypotension, rather than adrenaline, in view of the dysrhythmogenic potential of the latter. Amiodarone is probably of use in the treatment of dysrhythmias. Calcium channel blockers, phenytoin, and bretyllium should be avoided. In terms of new modes of therapy targeted at the specific action of local anesthetics, lipid infusions, propofol, and insulin/ glucose/potassium infusions may all have a role, but further research is necessary. [Pg.2118]

The pharmacologic and toxicologic mechanisms of the calcium channel blockers are complex. They include interference with electrical conduction through the atrioventricular node, decreased myocardial contractility, and direct vasodilation. Calcium channel blockers also interfere with pancreatic release of insulin. [Pg.380]

An insulin infusion should be considered for severe cases of calcium channel blocker toxicity." Case reports suggest that an intravenous bolus of regular insulin (0.5-1 units/kg) with 50 mL dextrose 50% (0.25 mg/kg for children) followed with a continuous infusion of regular insulin (0.5-1 units/kg per hour) may improve myocardial contractility. The effect of insulin is presently unclear, but it may improve myocardial metabolism that is adversely affected by calcium channel blocker overdoses, such as decreased cellular uptake of glucose and free fatty acids and a shift from fatty acid oxidation to carbohydrate metabolism. This insulin regimen is titrated to improvement in systolic blood pressure over 100 mm Hg and heart rate... [Pg.139]

A preliminary human study indicated a lack of interaction of an extract of dried flowering tops of hawthorn with low-dose insulin, metformin, gliclazide, ACE inhibitors, calcium channel blockers, 3-blockers, and diuretics (Walker et al. 2006). [Pg.277]

In a randomized trial of type 2 diabetes patients taking prescribed drugs, administration of 1200 mg daily of a 3 1 hawthorn leaf and flower extract for 16 weeks resulted in a moderate decrease in blood pressure with no adverse interactions reported. Prescription drugs being taken by the trial participants were hypoglycemic medications (low-dose insulin, metformin, gliclazide, and "others") and hypotensive medication (ACE inhibitors, calcium channel blockers, P blockers, diuretics, and "others") (Walker et al. 2006). [Pg.277]

Patients with high plasma coneentration of NEFAs have been associated with obesity-and type II diabetes (non-insulin-dependent)-mediated hypertension [24].Interestingly, the dihydropyridine family of calcium channel blockers (e.g. nifedipine and amlodipine) and (0-3 fatty acid supplement (e.g. fish oil) has been reported to either reduce plasma NEFAs concentration or inhibit NEFAs-induced endothelial dysfunction [25, 26] used to treat obesity- and/or type II diabetes-mediated hypertension. [Pg.4]

Volatile anaesthetics, calcium channel-entry blockers, and some anti-arrhythmic drugs may potentiate the negative inotropic effect of the 3-adrenoceptor antagonists. Concomitant digoxin therapy may cause AV dissociation. Potentiation of the hypoglycaemic effects of insulin and oral antidiabetic drugs may occur. [Pg.148]

Type II diabetes Stimulating the release of insulin from the pancreas. ATP-dependent K-channel blocker Calcium hydrogen phosphate, MCC, maize starch, polacrilin, potassium, povidone, glycerol (85%), magnesium stearate, meglumine, poloxamer Novo Nordisk... [Pg.14]


See other pages where Insulin Calcium-channel blockers is mentioned: [Pg.708]    [Pg.937]    [Pg.1258]    [Pg.588]    [Pg.997]    [Pg.1510]    [Pg.165]    [Pg.139]    [Pg.483]    [Pg.483]    [Pg.484]    [Pg.484]    [Pg.701]    [Pg.14]    [Pg.209]    [Pg.74]   
See also in sourсe #XX -- [ Pg.483 ]




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