Injectable anaesthetics ketamine

A placebo-controlled study in healthy subjects found that pre-treatment with topiramate 50 mg did not affect the reaction time after sub-anaesthetic doses of ketamine (slow intravenous injection of 120 micrograms/kg followed by 500 micrograms/kg over one hour)9... 

For surgery 20 control females were anaesthetized at the age of 165 days with an intraperitoneal injection of 45 mg/kg of ketamine. Ibotenic acid (IBO) was stereotaxically injected into the dorsal hippocampi (10 jUg IBO in 0.5 jul of phosphate buffer into each hemisphere). Ten additional females were treated alike without IBO injection (sham operation). For amygdala lesions 0.4 jUg IBO in 0.4 jul phosphate buffer were stereotaxically injected into each side. 

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