Tight binding inhibition ratio

Inhibition ratio. The inhibition ratio JCm/K] is particularly important as it is totally outside the control of the researcher or operator. Figures 5.2-5.4 demonstrate that an inhibition ratio Km/JC] < 1 is not detrimental the substrate binds more tightly than the inhibitor and the high degrees of conversion can still be achieved with out much difficulty, maybe at longer reaction times. If 2CM/2C > 1, however, the reaction crawls to a virtual stop at intermediate degrees of conversion and the reaction will not reach completion. 

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