Information Systems Merck

GRC Board of Trustees, Cray Research, IBM, Tripos Associates, Ciba-Geigy, DuPont Merck Pharmaceutical, Eli Lilly and Company, MDL Information Systems, Merck, and Chiron... 

Brown and others [12] describe the Merck, Sharp, and Dohme chemical structure information system which utilizes this approach. 

Brown, H. D., Marianne Costlow, Frank A. Cutler, Albert N. DeMott, Walter B. Gall, David P. Jacobus, and Charles J. Miller, "The Computer-Based Chemical Structure Information System of Merck, Sharp and Dohme Research Laboratories," Journal of Chemical Information and Computer Sciences, 16(1), 5-10 (1976). 

The FDA purged the 1984-86 cohort of INDs that did not represent a first commercial filing for the NME. Using available reference materials such as Pharmap-rojects (328) and the Merck Index (267), the FDA verified each IND sponsor was a commercial firm and then checked the Ingredient Dictionary, the Drug Product Reference File microfiche, and its own management information system to confirm that no commercial INDs had been filed for a related compound (salt or ester) prior to the 1984-86 interval. 

The system, still operating to this date, is based on the approach used at the Walter Reed Army Institute of Research in Washington, D.C. The system was extensively enhanced to meet the specific needs of the Merck Sharp and Dohme Research Laboratories (MSDRL) and the Chemical Data Department (CDD) which is responsible for processing chemical structure information at Merck and Co., Inc. 

Brown, H.D. Costlow, M. Cutler, F.A. Jr. DeMott, A.N. Gall, W.B. Jacobus, D.P. Miller, C.J. The Computer-Based Chemical Structure Information System of Merck Sharp and Dohme Research Laboratories . J. Chem. Inf. Comput. Sci. 1976,16, 5-10. 

Merck Sharp Dohme Research Laboratories, Dept, of Scientific Information, and Corporate Management Information Systems, MSDRL Systems and Programming Dept., Merck Co., Inc., Rahway, N.J. 07065... 

A recent study has compared the NCI-DCT system with the NIH-EPA Chemical Information System for the ability to perform substructure searches of large files of compounds (22). The Merck modification of the Walter Reed Army Institute of Research substructure search system was also compared. This report should be referred to for a detailed analysis of these major substructure systems. Another system, prepared with a smaller computer and a smaller set of chemicals, has been developed by Jurs and colleagues 23). All of these systems can be readily used in substructural analysis studies. It would appear that the exact coding system used in such studies is not critical, but no definitive comparisons of these systems for SAR utility have been performed. 

Our thanks go to Mr. T. Boyer, Assistant Director of Merck Sharp Dohme Research Laboratories Information Systems Programming, Mr. R. T. Ford, Manager, Research Data Processing,... 

Tanja Obradovic, Ph.D., Absorption Systems, Oaklands Corporate Center, 440 Creamery Way, Suite 300, Exton, PA 19341, USA, Telephone +16102801406, Fax +1 6102803779, E-mail obradovic absorption.com (current contact information - Merck Co., Inc., 351 North Sumneytown Pike, UG4D-80, North Wales, PA 19454-2505, Phone +1267 305 1576, Fax +1 215-305-6428, Email tanja obradovic merck.com)... 

In-house chemical information management systems began to emerge at some of the larger chemical and pharmaceutical firms. These included CONTRAST and SOCRATES at Pfizer, SYNLIB at SmithKline, COUSIN at Upjohn, MSDRL/CSIS at Merck, and CROSSBOW at ICI (27). The Chemical Abstracts database was made available online in 1967 (28). In 1980 this became CAS ONLINE. A compre-... 

It has come to my attention recently that many of our laboratory workers have not had much of an opportunity to explore the various information sources that are at our disposal. These include Material Safety Data Sheets (MSDS), the Merck Index on compact disc, and the Handbook of Chemistry and Physics, for example. In addition, some of our newer employees need to come up-to-speed on our system for ordering chemicals. 

Unger, R., Hsieh. D. S. T., Brown, L., and Rhine, W., in Better Therapy with Existing Drugs New Uses and Delivery Systems (A. Bearn, ed.), p. 179, Merck Company, Biomedical Information Corporation, New York, 1981. 

For comparative measurements, the spectral index for UV-Visible accompanied by the Merck solubility index data needs to be established. If these values cannot be found in the literature, it is usually recommended to take a spectrum using a spectrophotometer or, alternatively, using an HPLC-diode array detector. There are two ways of combining this information to achieve a better quantification system by adjusting distinct channels single A is recommended when only one compound is used, and program wavelength is recommended for any series of... 

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