Dupont Merck Pharmaceuticals

There are a few key enzymes for the proliferation of human immunodeficiency virus (HIV). Reverse transcriptase is one of them since HIV is a member of the DNA viruses. Efavirenz (1) is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) and was discovered at Merck Research Laboratories [1] for treatment of HIV infections. Efavirenz was originally licensed to DuPont Merck Pharmaceuticals which was later acquired by Bristol-Myers Squibb.11 The typical adult dose is 600 mg once a day and 1 is one of three key ingredients of the once-a-day oral HIV drug, Atripla (Figure 1.1). 

Scientists at DuPont Merck Pharmaceuticals [31] had also developed a new process to prepare 37, based on a modification of the Corey-Fuchs method, from cyclopropylaldehyde, prepared by thermal rearrangement of butadiene monoxide. 

Some optimization of the original Medidnal route was reported from the DuPont Merck Pharmaceutical Company Radesca, LA., Lo, Y.S., Moore,... 

Another drug currently used to treat heroin addiction is naltrexone. This drug was created by DuPont Merck Pharmaceutical Corporation, and has... 

Christopher T. Riley Experimental Station, DuPont Merck Pharmaceutical Company, P.O. Box 80400, Wilmington, DE 19880-0400, USA... 

Susan A. Lerke DuPont Merck Pharmaceutical Company,... 

Escherichia coli derived r hMCP-1 was purchased from Pepprotech (Cherry Hill, NJ) or provided by T. Handel and A. Yetter (DuPont Merck Pharmaceutical Co.) Pepsin was obtained from Boehringer Mannheim (Indianapolis, IN). 

GRC Board of Trustees, Cray Research, IBM, Tripos Associates, Ciba-Geigy, DuPont Merck Pharmaceutical, Eli Lilly and Company, MDL Information Systems, Merck, and Chiron... 

GRC Board of Trustees, Bristol-Myers Squibb, Chemical Computing Group, DuPont Merck Pharmaceutical, IBM, R. W. Johnson Pharmaceutical Research Institute, Molecular Simulations Inc., Novartis, Rohm and Haas, Tripos, Inc., and Zeneca... 

DuPont Merck Pharmaceutical Co., Experimental Station, Cardiovascular Diseases Research, PO Box 80402, Wilmington DE 19880-0353., U. S. A. 

This work was completed during the period that our group was part of the DuPont Pharmaceutical Company and its precursor, the DuPont-Merck Pharmaceutical Company. 

Vial B contains 1 ml phosphate buffer, pH 7.6 0.4. It is placed into a lead shield. A volume of 2 ml of Tc-pertechnetate (925 MBq-3.7 GBq 25-100 mCi) is added asepti-cally to vied B. Labeling is performed by adding aseptically 1 ml from vied A to vied B, and allowed to react for 30 min at room temperature (DuPont Merck Pharmaceutical 1995). 

The kit formulation (vial A) contains bicisate dihydrochloride exclusively as the L,L-en-antiomer (DuPont Merck Pharmaceutical 1995). After reconstitution with 3 ml saline, the pH of vial A is 2.7 0.25. One third of bicisate (0.3 mg) is used for labeling. The rest is discarded. Storage of residual portions of Neurolite in a freezer and subsequent labehng within 4 weeks has been suggested (Verbeke et al. 1997). 

Dormehl, 1C, Oliver DW, Langen, K-J, Hugo N, Croft SA (1997) Technetium-99m-HMPAO, techne-tium-99m-ECD and iodine-123-lMP cerebral blood flow measurements with pharmacological interventions in primates. J Nucl Med 38 1897-1901 DuPont Merck Pharmaceutical (1995) Product monograph Neurolite, issued by DuPont Merck Pharmaceutical, Wilmington, Del. 

Gramicidin-S, cyclo[(Orn-Leu-D-Phe-Pro-Val)2], is a C2-symmetric, antibacterial, cyclic decapeptide. Structural studies have shown that the peptide conformation consists of two type IP p-turns with a connecting p-sheet. Based on molecular modeling studies and the results from earlier experimental studies of cyclic octapeptides, Ripka et al. at DuPont Merck Pharmaceuticals believed that the four amino acids that make up one of the p-turns could be replaced by a benzodiazepine (BZD) moiety. These authors designed the gramicidin-S analogue cyclo(Lys-Leu-D-Phe-Pro-Val-Lys-BZD) (95) based on... 

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