Infectious disease diagnostics

O. Fejerskov, B. Nyvad, Is dental caries an infectious disease Diagnostic and treatment consequences for the practitioner, in L. Schon(Ed.), Nordic Dentistry 2003 Yearbook, Quintessence Publishing, Copenhagen, 2003, pp. 141-151. 

CD CHANG, KY CHANG, L JIANG, VA SABLILLA, DO SHAH Infectious Disease Diagnostics R D, Abbott Laboratories,... 

Mass spectrometry (MS), a molecular-level biophysical technology, offers several advantages for pathogen detection, including speed, sensitivity, and specificity, and it rapidly revolutionizes the practice of infectious disease diagnostics (Wilkins et al. 2005 Demirev and Fenselau 2008a, b Shah and Ghaibia 2010 Cliff et al. 

Nuxoll E (2013) BioMEMS in drug delivery. Adv Dmg Deliv Rev 65 1611-1625 Park S, Zhang Y, Lin S et al (2011) Advances in microfluidic PCR for point-of-care infectious disease diagnostics. Biotechnol Adv 29 830-839... 

Peruski, L. F. Peruski, A. H. Rapid diagnostic assays in the genomic biology era Detection and identification of infectious disease and biological weapon agents. BioTechniques 2003, 35, 840-846. 

The voluminous number of publications in this area over the last 10 years have exceeded 10,000, thus attesting to the intensity of effort directed towards applying molecular methods towards investigation of infectious diseases. Many of these investigations have translated into applications for diagnostic use in the clinical laboratory. The reader is referred to selected reviews on the subject (F2, N3, Wl). The availability of assays for the rapid diagnosis of pulmonary tuber-... 

Diagnostic imaging (e.g. of cancer, infectious diseases, cardiovascular disease and deep vein thrombosis)... 

Aerestrup F.M., Y. Agerso, P. Gemer-Smidt, M. Madsen, and L.B. Jensen (2000). Comparison of antimicrobial resistance phenotypes and resistance genes in Enterococcus faecalis and Enterococci faecium from humans in the community, broilers, and pigs in Denmark. Diagnostic Microbiology and Infectious Disease 37 127-137. 

Jones R.N. and DJ. Biedenbach (2003). Comparative activity of geienoxacin (BMS 284756), a novel desfluoioquinolone tested against 8,331 isolates from community-acquired respiratory tract infections North American results from the SENTRY Antirrricrobial SrrrveiUance Program (1999-2001). Diagnostic Microbiology and Infectious Disease 45 273-278. 

Cabrera, M., Canova, S., Rosenzvit, M. and Guarnera, E. (2002) Identification of Echinococcus granulosus eggs. Diagnostic Microbiology and Infectious Disease 44, 29-34. 

We feel confident in stating that through the use of defined O-antigenic saccharides it is now possible to study on a molecular level selected aspects of host-parasite interactions. These studies will conceivably increase our understanding of certain infectious diseases and definitely hold the prospect for the development of more refined diagnostic procedures and hopefully also vaccines. 

Bravata, D. M., Sundaram, V., McDonald, K. M., Smith, W. M., Szeto, H., Schleinitz, M. D., et al. (2004). Evaluating detection and diagnostic support systems for bioterrorism response [Electronic version]. Emerging Infectious Diseases, 10, 100-108. 

Nucleic acid probe methods which rely on the specificity of nucleic acid hybridization reaction, combined with the powerful methods of nucleic acid amplification, are expected to spawn many new diagnostic tests which may be useful in the detection and treatment of infectious diseases, cancer, and inherited disorders. The impact of development and applications of diagnostic tests based on nucleic acid probes and on Mab technology wiU be felt increasingly as deeper understanding of diseases at a molecular level is gained. 

These passive obstacles to antibiotic action complicate treatment of infectious disease in the absence of highly accurate diagnostic tools to identify the infectious pathogen. Intrinsic resistance is problematic but is predictable and easily identihed in the preclinical drug discovery stages. As a result, the spectrum of susceptible microbial species is weh known before the compound enters the clinic. 

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