Industrial drug design

APPLICATIONS TO MEDICINE AND INDUSTRY DRUG DESIGN AND PROTEIN ENGINEERING... 

Since the late 1980s, computer-aided drug design (CADD) techniques have found wide application in the pharmaceutical and biotech industries. In the... 

Within the pharmaceutical industry we have progressed from the point where computers in the laboratory were rarely present or used beyond spreadsheet calculations. Now computers are ubiquitous in pharmaceutical research and development laboratories, and nearly everyone has at least one used in some way to aid in his or her role. It should come as no surprise that the development of hardware and software over the last 30 years has expanded the scope of computer use to virtually all stages of pharmaceutical research and development (data analysis, data capture, monitoring and decision making). Although there are many excellent books published that are focused on in-depth discussions of computer-aided drug design, bioinformatics, or other related individual topics, none has addressed this broader utilization of... 

The editors have chosen topics from both important therapeutic areas and from work that advances the discipline of medicinal chemistry. For example, cancer, metabolic syndrome and Alzheimer s disease are fields in which academia and industry are heavily invested to discover new drugs because of their considerable unmet medical need. The editors have therefore prioritized covering new developments in medicinal chemistry in these fields. In addition, important advances in the discipline, such as fragment-based drug design and other aspects of new lead-seeking approaches, are also planned for early volumes in this series. Each volume thus offers a unique opportunity to capture the most up-to-date perspective in an area of medicinal chemistry. 

Valko, K., Measurements of physical properties for drug design in industry, in Valko, K. (ed.), Separation Methods in Drug Synthesis and Purification, Elsevier, Amsterdam, 2001, Ch. 12. 

Dean, P.M., et al., "Industrial-Scale, Genomics-Based Drug Design and Discovery," Trends Biotechnol., 19, 288-292 (2001). 

Grossman, S.J., Overview drug metabolism in the modem pharmaceutical industry. In Drug Metabolism in Drug Design and Development, Zhang, D., Zhu, M. and Humphreys, W.G. (eds). J. Wiley Sons, Inc., 2008, pp. 3-13. 

The pharmaceutical industry has pioneered in the application of computer-assisted drug design methods in product research. To a significant degree this is a consequence of the direct use of computational chemistry in enhancing the efficiency of the chemical lead optimization process. 

Draft guidance for industry drug interaction studies-study design, data analysis, and implications for dosing and labeling http //www.fda.gov/cder/ guidance/index.htm (to be published in 2006). 

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