Interactions, drug human studies

O Reilly, R. A., Studies on the coumarin anticoagulant drugs interaction of human plasma albumin and warfarin sodium. J. Clin. Invest. 46, 829-837 (1967). 

Jamis-Dow CA, Pearl ML, Watkins PB, et al. Predicting drug interactions in vivo from experiments in vitro human studies with paclitaxel and ketoconazole. Am J Clin Oncol 1997 20 592-599. 

Phenotyping enzyme activity is a practical approach to studying metabolic drug interactions in humans, allowing for diverse patient characteristics such as... 

The study of the chemistry of plants is termed phytochemistry, and the fact that a number of effective drugs have been found in natural plant products (some say as many as a third of the current manufactured drugs) begs the question Why Why should it be that plants produce materials that interact with humans Why should certain plant products make us healthy, some make us happy, some make us sleepy, and some make us dead ... 

These batteries of preclinical tests will often generate questions that can only be answered by studying potential interactions in humans. Understanding whether a new drug will interact with other drugs that are likely to be co-prescribed for the disease of interest is essential for good product labeling. Oral contraceptives are used by about 50% of women in their reproductive years in the developed world, and must always be considered as a concomitant medication. 

First-in-human studies (SAD MAD) Microdosing Human ADME Drug-drug interaction... 

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