Neurotoxicity METH-induced

Subsequent experiments revealed that DA is necessary for METH to cause neurotoxicity when DA synthesis was inhibited with tt methyl-p-tyrosine (MT), the usual decrease in striatal TH activity observed after METH was prevented (figure 3A) (Kogan and Gibb 1979). Reinstatement of DA synthesis by administering, /-dopa. which circumvents the inhibited TH step, returned the METH-induced decreased in TH activity. 

Oxidative Stress A Possible Cause of METH-Induced Neurotoxicity.65... 

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