Neurotoxicity carbamate-induced

FIGURE 57.5. Subclasses of neuropathy target esterase (NTE) inhibitors. Type A inhibitors include phosphates, phosphonates, and phosphoramidates these are neuropathic and capable of aging. T pe B inhibitors include phosphinates, sulfonates, and carbamates these are nonneuropathic and not capable of aging. However, inhibition of NTE with a type B inhibitor will protect against organophosphorus compound-induced delayed neurotoxicity (OPIDN) from subsequently administered type A inhibitors. Reproduced with permission from Richardson (2005). 

Tiffany-Castiglioni, E., Venkatraj, V., Wild, J.R. (2006). In vitro models for testing organophosphate-induced neurotoxicity and remediation. In Toxicology of Organophosphate and Carbamate Compounds (R.C. Gupta, ed.), pp. 315-37. Elsevier/ Academic Press, San Diego, CA. 

A3. Abou-Donia, M. B., and Lapadula, D. M., Mechanisms of organophosphorus ester-induced delayed neurotoxicity Type I and Type II. Ann. Rev. Toxicol. 30,405-440 (1990). A4. Aldridge, W. N., Organophosphorus compounds and carbamates, and their reactions with esterases. Brit. Med. Bull. 25, 236-239 (1969). 

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