Indium antibody labelling

DivgiCR, Welt S, Kris M, et al. Phase I and imaging trial of indium Ill-labeled anti-epidermal growth factor receptor monoclonal antibody 225 in patients with squamous cell lung carcinomas. JNatl Cancer Inst 1991 83 97-194. 

Peltier, P. Curtet, C. Chatal, J.-F. Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/ Anti-insium-DTPA antibody and an indium-111 labeled DTPA-dimer. J. Nucl. Med. 1993, 34, 161- 113. 

Pimm, M.V. Fells, H.F. Perkins, A.C. Baldwin, R.W. Iodine-131 and Indium-111 labelled avidin and streptavidin for pre-targetted immunoscintigraphy with biotinylated anti-tumour monoclonal antibody. Nucl. Med. Conunun. 1988, 9 (11), 931-941. 

Ballester, M. Marti, V. Carrio, I. Spectrum of alcohol-induced myocardial damage detected by indium-111-labeled monoclonal antimyosin antibodies. J. Am. Coll. Cardiol. 1997, 29 (1), 160-167. 

Griffin TW, Brill AB, Stevens S, Collins JA, Bokhari F, Bushe H, Stochl MC, Gionet M, Rusckowski M, Stroupe SD, et al Initial clinical study of indium-lll-labeled clone 110 anticarcinoembryonic antigen antibody in patients with colorectal cancer. J Clin Oncol 1991 9(4) 631-40. 

Patt, Y. Z., Lamki, L. M Haynie, T. P Unger, M. W., Rosenblum, M. G., Shirkhoda, A., and Murray, J. L. (1988) Improved tumour localisation with increasing dose of Indium-111-labeled anti-CEA monoclonal antibody ZCE-025 in metastatic colorectal cancer. J. Clin. Oncol. 6,1220-1230. 

Khaw, B. A., Strauss, H. W Cahill, S. L Soule, H. R. Edgington, T., and Cooney, J. (1984) Sequential imaging of indium-111-labeled monoclonal antibody in human mammary tumors hosted in nude mice. J. Nucl. Med. 25, 592-603. 

Saga T, Sakahara H, Nakamoto Y, Sato N, Zhao S, Aoki T, et al. Radioimmunotherapy of human glioma xenografts in nude mice by indium-111 labelled internalizing monoclonal antibody. Eur J Cancer 1999 35 1281-1285. 

Carney P L, Rogers P E, Johnson D K (1989). Dual isotope study of iodine-125 and indium-lll-labeled antibody in athymic mice. I. Nucl. Med. 30 374-384. 

Hnatowich D J, Griffin T W, Kosciuczyk C, et al. (1985). Pharmacokinetics of an indium-lll-labeled monoclonal antibody in cancer patients. J. Nucl. Med. 26 849-858. 

Indium-111 has several properties that make it attractive for antibody labeling and diagnostic imaging. The half-life of 67 hr is long enough to image up to 5 days postinjection, which is often necessary due to the slow biological clearance of intact antibodies. Indium binds only weakly to... 

Indium-lU labelling of antibodies using cyclic DTPA anhydride ... 

Indium-lll labelling of antibodies using cyclic DTPA anhydride 221 Reduction-mediated technetium-99m labelling of antibodies with 2-mercaiJtoethanol 226... 

Kobayashi, H., Wu, C., Kim, M.K., Paik, C.H., Carrasquillo, J.A., and Brechbiel, M.W. (1999) Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1 B4M-DTPA and its conjugation with anti-Tac monoclonal antibody. Bioconjug. Chem. 10, 103-111. 

Myoscint (Imicro pentetate, Fab fragment of anti-myosin IgG2 monoclonal antibody bound to DTPA for labeling with Indium 111)... 

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