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Indicated carbocycles

As described in Section 1.02.2.3, any heterocycle can be named by indicating (with appropriate prefixes) the positions of heteroatoms in the corresponding carbocycle. The carbocycle can be named systematically, as described in later Sections however, the replacement procedure can also be applied to naming heterocyclic analogues of trivially named carbocycles. A list of polycarbocycles with their trivial names is given in Table 5 (taken from Rule A-21.2 in the lUPAC Blue Book (B-79MI10200)) replacement names may be derived as shown in examples (27) and (28). As demonstrated by example (28), it is unnecessary to add hydro prefixes if the heterocycle cannot accommodate as many double bonds as the original carbocycle. [Pg.18]

In accord with experimental observations, SCFMO calculations indicate that an /V-acyl function should deactivate 5f/-dibenz[/>,/]azepine towards electrophilic substitution at the carbocyclic rings, and that substitution should occur preferentially at the CIO position.32 The calculated dipole moment (0.98 D) for 5f/-dibenz[A,/]azepine compares favorably with the measured value (0.96 D), and is expected for a nonplanar ring system.58... [Pg.211]

Differential scanning calorimetry (DSC) experiments on the various dimeric carbocycles indicated that, depending on the length of the alkyl groups, thermal polymerization had occurred between 100 and 125°C as an abrupt, exothermic process. The narrow temperature range for each exotherm was suggestive of a chain reaction however, IR spectroscopy revealed the absence of acetylene functionalities in the polymerized material. Consequently, none of the substi-... [Pg.102]

Further dissection of the morphine molecule showed that potent analgesics could be obtained even when one of the carbocyclic rings was omitted. One such compound, pentazocine (52), has found considerable use as an analgesic in the clinic. There is considerable evidence to indicate this drug has much less... [Pg.325]

Lactams Lactams represent a special type of C=N system due to the tautomerization between the lactam (keto amine) and lactim (hydroxyimine) forms. The lactim form is much more favored for cyclic than for non-cyclic amides of carbocyclic acids. In the reaction of complex 2b with N-methyl-e-caprolactam, a simple ligand exchange reaction occurs and complex 87 can be isolated. With P-propiolactam, the alkenyl-amido complex 88 is formed, which indicates an agostic interaction. The reaction of complex 1 with e-caprolactam gives, after elimination of the alkyne and of molecular hydrogen, complex 89 with a deproto-nated lactam in a r]2-amidate bonding fashion [47]. [Pg.377]

Numbering always begins at the heteroatom in the case of morpholine, numbering starts at oxygen, the heteroatom of higher atomic number. Remember that an accepted alternative in nomenclature is to indicate a heteroatom by the prefix aza-, oxa, or thia-in the appropriate carbocycle (see Section 1.4). Thus, we could name piperidine as azacyclohexane, and tetrahydrofuran as oxacyclopentane. [Pg.404]

Since trivial names are so well established, it is now very difficult to abandon them in favour of a logical nomenclature system that provides structural information. Nevertheless, a predictive method of this type is very desirable, especially for molecules where there may be two or more heteroatoms present in the ring. One approach is to use a prefix, which is indicative of the heteroatom [aza (N), oxa (O), thia (S), bora (B), phos-pha (P), sila (Si), etc.], to the name of the corresponding carbocycle. Thus, pyridine becomes azabenzene and piperidine is azacyclohexane. [Pg.3]

A heterocycle can be derived formally from a carbocycle by replacement of one or more carbon atoms with heteroatoms. In a replacement name, this is indicated by use of prefixes terminating in a, cited in the... [Pg.181]

The disadvantages of the Stelzner system, as applied to carbocycles, are not very serious. The original system did not indicate how to deal with cases of fusion involving two adjacent bonds in each component, but is capable of logical extension to cover such cases. However, the IUPAC/Chemical Abstracts system is simpler in that it always names the form of the molecule with maximum unsaturation and yields a uniform numbering system for the skeleton it is also more able to deal with complex cases. [Pg.186]

Another type of elimination reaction favoured under plasma conditions is the decarboxylation. Carbocyclic acids easily lose carbon dioxide to form the parent hydrocarbons. In acid anhydrides decarboxylation is followed by a decar-bonylation. Cyclic or bicyclic anhydrides fragment forming unsaturated compounds, a reaction which has been studied with phthalie anhydride 24>. This anhydride decomposes to dehydrobenzene which, in the absence of other compounds, dimerizes, trimerizes or polymerizes. Orientation experiments indicated similar results for aliphatic acid anhydrides. [Pg.47]

Carbocyclic variants related to ajmalicine such as yohimbine are likely to arise from dehy-drogeissoschizine by the mechanism indicated in Figure 6.77. Yohimbine is found in Yohimbe bark (Pausinystalia yohimbe, Rubiaceae) and Aspidosperma bark (Aspidosperma species Apocy-naceae) and has been used in folk medicine as an aphrodisiac. It does have some pharmacological activity and is known to dilate blood vessels. More important examples containing the same carbocyclic ring system are the alkaloids found in species of Rauwolfla, especially R. serpentina (Apocynaceae). Reserpine and deserpi-dine (Figure 6.78) are trimethoxybenzoyl esters of yohimbine-like alkaloids, whilst rescinnamine is... [Pg.351]


See other pages where Indicated carbocycles is mentioned: [Pg.11]    [Pg.20]    [Pg.5]    [Pg.30]    [Pg.37]    [Pg.121]    [Pg.48]    [Pg.77]    [Pg.11]    [Pg.20]    [Pg.518]    [Pg.255]    [Pg.56]    [Pg.76]    [Pg.76]    [Pg.173]    [Pg.464]    [Pg.159]    [Pg.549]    [Pg.207]    [Pg.492]    [Pg.703]    [Pg.16]    [Pg.142]    [Pg.428]    [Pg.30]    [Pg.527]    [Pg.492]    [Pg.703]    [Pg.641]    [Pg.390]    [Pg.97]    [Pg.182]    [Pg.1475]    [Pg.609]    [Pg.1114]    [Pg.22]   
See also in sourсe #XX -- [ Pg.27 ]




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