Incomplete responder

Assign a technical review team and a commercial review team. Use a checklist to ensure bidders responded to each specific item in the request for proposal. Eliminate or resolve incomplete proposals. 

Incomplete Dissociation into Free Ions. As is well known, there are many substances which behave as a strong electrolyte when dissolved in one solvent, but as a weak electrolyte when dissolved in another solvent. In any solvent the Debye-IIiickel-Onsager theory predicts how the ions of a solute should behave in an applied electric field, if the solute is completely dissociated into free ions. When we wish to survey the electrical conductivity of those solutes which (in certain solvents) behave as weak electrolytes, we have to ask, in each case, the question posed in Sec. 20 in this solution is it true that, at any moment, every ion responds to the applied electric field in the way predicted by the Debye-Hiickel theory, or does a certain fraction of the solute fail to respond to the field in this way In cases where it is true that, at any moment, a certain fraction of the solute fails to contribute to the conductivity, we have to ask the further question is this failure due to the presence of short-range forces of attraction, or can it be due merely to the presence of strong electrostatic forces ... 

Figure 4. Effects of dihydro-brevetoxin B (H2BVTX-B) on Na currents in crayfish axon under voltage-clamp. (A) A family of Na currents in control solution each trace shows the current kinetics responding to a step depolarization (ranging from -90 to -I-100 mV in 10 mV increments). Incomplete inactivation at large depolarizations is normal in this preparation. (B) Na currents after internal perfusion with H2BVTX-B (1.2 a M). inactivation is slower and less complete than in the control, and the current amplitudes are reduced. (C) A plot of current amplitudes at their peak value (Ip o, o) and at steady-state (I A, A for long depolarizations) shows that toxin-mOdified channels (filled symbols) activate at more negative membrane potentials and correspond to a reduced peak Na conductance of the axon (Reproduced with permission from Ref. 31. Copyright 1984 American Society for Pharmacology and Experimental Therapeutics).

The period required from receipt to approval of the application is treated as that for handling of the standard clerical service, except for replying to PAFSC inquiries and that for correcting incomplete applications. The period for handling the standard clerical service is 12 months. The applicant also has another 12 months to respond to queries and requests from the agency. 

Maintenance therapy Many patients respond to less than or equal to 500 to 750 mg/day. In patients who respond but who evidence incomplete disease suppression after the first 6 to 9 months of treatment, increase daily dosage by 125 or 250 mg/day at 3-month intervals. Dosage more than 1 g/day is unusual, but 1.5 g/day or less has been required. 

In 1993, investigators at the Massachusetts General Hospital (MGH) published the results of an institutional study, which became the model for several subsequent trials (67). In this first report, 53 patients (T2-4, NXMO) underwent maximal TURBT, followed by two cycles of CMV, then 4000 cGy + two cycles of single-agent cisplatin. Patients then underwent endoscopic reevaluation and those who had an incomplete response to therapy and who were surgical candidates underwent cystectomy, whereas complete responders were consolidated with an additional 2480 cGy and one additional cycle of cisplatin. Following 11 dropouts, 42 patients completed therapy and there was... 

Chronic ulcers are a significant health problem in young and elderly individuals that culminates in disability, decreased productivity, and loss of independence [1, 2], The economic costs associated with chronic wounds are enormous for the healthcare system as well as for patients [3], The healing process is slow and often incomplete and patients not responding to conservative therapy become candidates for amputation [4],... 

In selected patients, erythropoietin may also be useful for the treatment of anemia due to primary bone marrow disorders and secondary anemias. This includes patients with aplastic anemia and other bone marrow failure states, myeloproliferative and myelodysplastic disorders, multiple myeloma and perhaps other chronic bone marrow malignancies, and the anemias associated with chronic inflammation, AIDS, and cancer. Patients with these disorders who have disproportionately low serum erythropoietin levels for their degree of anemia are most likely to respond to treatment with this growth factor. Patients with endogenous erythropoietin levels of less than 100 IU/L have the best chance of response, though patients with erythropoietin levels between 100 and 500 IU/L respond occasionally. These patients generally require higher erythropoietin doses (150-300 IU/kg three times a week) to achieve a response, and responses are often incomplete. 

Despite the obvious benefits of this drug in the different treatment settings, the clinical outcomes of tamoxifen treatment in terms of efficacy and side effects are incomplete and inconstant, and almost 30-50 % of patients either fail to respond or become resistant to tamoxifen [188], One of the proposed mechanisms that may account for the impaired response to tamoxifen therapy is an altered bioactivation of the parent drug into endoxifen, either by genetic or environmental factors [188, 189],... 

The results presented demonstrate that auditory systems of animals and humans respond to pulsed microwaves. However, there is little likelihood of the microwave acoustic effect arising from direct interaction of microwave pulses with the cochlear nerve or neurons at higher structures along the auditory pathway. The pulsed microwave energy, instead, initiates a thermoelastic wave of pressure in the head that travels to the cochlea and activates the hair cells in the inner ear. This theory covers many experimental observations, but it may be incomplete and thus require further extension to account for certain additional experimental findings. Tyazhelov, et al. (1 1) found in their beat frequency experiment that matching of microwave pulses (10 ps, 8000 pps) to a phase-shifted 8 kHz sinusoidal sound input... 

WHILE MOST HAVE ALREADY RESPONDED, THE SURVEY WILL BE INCOMPLETE WITHOUT YOUR REPLY. IT IS IMPORTANT THAT EVERY MAN TAKE PART. 

Furnaces usually have to deal with on-demand load changes, i.e., a customer instantaneously needs more steam or more heat input to a unit. The control system on the furnace must be set up to respond quickly to these load changes. The process shown in Fig. 7.1 show s a furnace in which a stream is being heated in a furnace. The outlet temperature of the process stream is controlled by adjusting the fuel flowrate. The air flow is ratioed to the fuel flow. This ratio is adjusted by the output signal from an excess oxygen controller that looks at the composition of the stack gas. The use of too much air increases energy consumption, but too little air can lead to air pollution problems due to incomplete combustion. 

Retrospective analysis of occurred radiation accidents shows that the most of their-related damages was due to impertinence, incompleteness and biased character of issued information. If the concerned speciahsts had responded more efficiently on the emergency events, their implications could have been minimized (or prevented). 

BZs should be reserved for patients at low risk of substance abuse, those who require rapid relief, or those who have not responded to other therapies. Clonazepam is the most extensively studied BZ for treatment of generalized SAD. It improved fear and phobic avoidance, interpersonal sensitivity, fears of negative evaluation, and disability measures. Adverse effects include sexual dysfunction, unsteadiness, dizziness, and poor concentration. Clonazepam should be tapered at a rate not to exceed 0.25 mg every 2 weeks. Gabapentin was effective for SAD, and onset of effect was 2 to 4 weeks. j8-Blockers blunt the peripheral autonomic symptoms of arousal (e.g., rapid heart rate, sweating, blushing, and tremor) and are often used to decrease anxiety in performance-related situations. For specific SAD, 10 to 80 mg of propranolol or 25 to 100 mg of atenolol can be taken 1 hour before the performance. A test dose should be taken at home on a day before the performance to be sure adverse effects wUl not be problematic. Incomplete response to a first-line agent may benefit from augmentation with buspirone or clonazepam. 

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