In hypersensitivity reactions

Specific immunotherapy (SIT) with aeroallergens directly addresses adaptive mechanism in hypersensitivity reactions. A meta-analysis of SIT studies revealed positive effects of subcutaneous... 

Chanan-Khan A, Szebeni J, Savay S, et al. Complement activation following first exposure to pegylated liposomal doxorubicin (Doxil) possible role in hypersensitivity reactions. Ann Oncol 2003 14 1430. 

Szebeni J, Baranyi L, Savay S, et al. Role of complement activation in hypersensitivity reactions to doxil and hynic PEG liposomes experimental and clinical studies. J Liposome Res 2002 12 165. 

Knee caps, which are indicated for soft tissue support, are not contraindicated in patients taking non-steroidal anti-inflammatory drugs. Knee caps do not result in hypersensitivity reactions. 

Mercurous salts are less toxic than mercuric salts, probably as a result of lower solubility. Exposure of human subjects to mercurous chloride (calomel) may result in hypersensitivity reactions. 

Basophil numbers are increased in inflammatory and decreased in hypersensitivity reactions. 

In drug-induced liver damage, a similar immunological mechanism is conceivable the respective medicament acts as a hapten, and an endogenic protein turns into an autoantigen. In hypersensitivity reactions, IgE can increase. 

The role of aspartame in hypersensitivity reactions is controversial, although there have been case reports (32). In a multicenter, randomized, double-blind, placebo-controUed, crossover study, aspartame was more likely than placebo to cause urticaria or angioedema (33). 

Budinger L, Herd M. Immunologic mechanisms in hypersensitivity reactions to metal ions an overview. Allergy 2000 55(2) 108-15. 

Any rabies vaccine can apparently cause mild local discomfort and swelling, and either of the animal preparations can result in hypersensitivity reactions, for example pyrexia, serum sickness, or urticaria sensitization can occur. 

Szebeni, J., Alving, C. R., Savay, S., Barenholz, Y., Priev, A., Danino, D., Talmon, Y. Eormation of complement activating particles in aqueous solutions of Taxol possible role in hypersensitivity reactions. Int. Immunophartnacol. 2001, 1, 721—735. 

Chemotherapy agents are implicated in hypersensitivity reactions in 5% to 15% of patients who receive them. Up to 65% of patients receiving L-asparaginase experience immediate hypersensitivity reactions such as urticaria and anaphylaxis. ... 

Basophils are the least numerous and least well characterized of the circulating leukocytes. While they are not derived from the same progenitor cell as tissue mast cells, basophils and mast cells have several similar functions, including their participation in hypersensitivity reactions. Basophils have also been attributed roles in plasma lipolysis, parasite immunity, tumor cell cytotoxicity, and hemostasis. Increases have been associated with persistent lipemia, parasitism, allergic diseases, certain neoplastic diseases, and administration of certain drugs (e.g., heparin, penicillin). 

Ketotifen is an ophthalmic antihistamine that inhibits release of mediators from cells involved in hypersensitivity reactions. It is indicated in temporary prevention of itching of eyes caused by allergic conjunctivitis. 

The injection of free enzyme of heterogenous origin may result in hypersensitivity reactions, production of antibodies, and rapid removal and Inactivation. Furthermore, free enzymes cannot be kept at the desired sites of action and are less stable at a body temperature of BI C. The use of artificial cells containing enzymes and proteins has been investigated [3,4]. Some examples of research being carried out will be briefly mentioned. 

Isbister JP, Biggs JC (1976) Reactions to rapid infusion of stable plasma protein solution during large volume plasma exchange. Anaesth Intensive Care 4 105-107 Ishizaka K (1963) Gammaglobulin and molecular mechanisms in hypersensitivity reactions. Prog Allergy 7 32-106... 

Zanoni G, Puccetti A, Dolcino M, Simone R, Peretti A, Ferro A, Tridente G. Dextran-specific IgG response in hypersensitivity reactions to measles-mumps-rubella vaccine. J Allergy Clin Immunol 2008 122(6) 1233-5. 

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