In cats

Eeather meal, first hydroly2ed and then oxidi2ed, produces cysteic acid [13100-82-8] an excellent precursor for taurine in cats (20). Hydroly2ed feather meal may supplement the taurine provided by other dietary animal proteins and help replace part or all of the synthetic taurine in cat food formulations with considerable cost savings. 

In cat food, methionine may substitute for choline as methyl donor at a rate of 3.75 parts for 1 part choline by weight when methionine exceeds 0.62%. 

Oral appHcations of 1500 mg/kg/d for two weeks caused death of rats. Repeated oral appHcations (4 wks) of 30 p-L/kg to rats caused no toxic symptoms, 100 pL/kg resulted in minor toxic effects, and 300 pL/kg induced impairment of several organs andlethaHty. Repeated oral appHcations (26 x) of 0.1 mL/kg caused no toxic symptoms in cats or rabbits. Inhalation of 1500 ppm (2 wks) were without effects, whereas in a similar study with... 

Because histamine in the CNS is important for the regulation of sleep/wakehilness, appHcations in this area could be found. In cats, the receptor has been shown to affect the sleep pattern, and it has also been impHcated in this respect in rats and mice (8). 

General References Pohl, in Moore (ed.), Electmstatics and Its Applications, Wiley, New York, 1973, chap. 14 and chap. 15 (with Crane). Pohl, in Cat-simpoolas (ed.). Methods of Cell Separation, vol. I, Plenum Press, New York, 1977, chap. 3. Pohl, Dielectrophoresis The Behavior of Matter in Nonunifoim Electric Fields, Cambridge, New York, 1978. 

Neither tropine nor 4-tropine is mydriatic, though the former is stated to produce mydriasis in cats when injected in large doses. The pharmacological properties of these two bases have been compared by Hazard, who points out that these cis-trans isomerides show qualitative differences in pharmacological action, whereas among optical isomerides there are usually only quantitative differences in activity. It has been stated that rabbits are immune from poisoning by belladonna and, in that connection,... 

Morphine. This alkaloid exerts both a depressing and a stimulating action on the central nervous system, the depression affecting the brain especially the sensation of pain and the respiration the cerebral motoi functions are less affected. The stimulant action in the cord is best seen in the cold-blooded animals, when it may develop into tonic convulsions. In higher animals, but rarely in man, there may be some indication of this stimulant action. In cats it may also involve the motor areas, and they... 

The median lethal dose of lunacrine hydrochloride is 78-7 3-8 mgm. per kilo given intravenously in mice. Oral doses of 1 gramme of lunamarine are not fatal. The m.l.d. of lunacridine by mouth is 1,097 167 mgra. per kilo. Limamarine stimulates isolated rabbit intestine and uterus, but lunacrine and lunacridine inhibit peristaltic movement of the isolated intestine. All three alkaloids reduce arterial blood pressure in cats. ... 

Aniline Point is the minimum temperature for complete miscibility of equal volumes of aniline and the hydrocarbon sample. In cat cracking, aniline solution is used to determine aromaticity of FCC feedstocks. Aromaticity increases with reducing aniline point. 

The bromide (2a) reacted smoothly with 2,4-diethoxy-5-methylpyrimi-dine to give, after de-ethylation and deacylation, l-(2-deoxy-/ -D-arabino-hexopyranosyl)thymine (3) (15). The new nucleoside (3) is the first truly competitive inhibitor of a pyrimidine phosphorylase (7), that is, it inhibits the phosphorylase, yet is not a substrate for the enzyme. It was recently shown that 3 enhances the incorporation of 2 -deoxy-5-iodouridine in vivo in cats (8). 

Anand M, Akveld AC, Sexena PR. 1981. Effect of a neurotic pesticide, endosulfan, on tissue blood flow in cats, including regional cerebral circulation. Vet Hum Toxicol 23 252-258. 

Khanna RN, Misra D, Anand M, et al. 1979. Distribuhon of endosulfan in cat brain. Bull Environ Contam Toxicol 22 72-79. 

Mollusca and Arthropoda. A variety of pharmacological actions are induced by the toxins found in molluscs (17). For example, surugatoxin is a potent mydriatic (5J), ganglion blocker (84), and a potent hypotensive agent in cats. 

In fact, there is a good deal of evidence to support this suggestion. First, more than half the neurons in the PPT fire rhythmically only when PGO waves are evident and their firing starts immediately before the PGO waves appear. Second, in cats, REM sleep is augmented by direct injection of either carbachol, or more selective muscarinic agonists, or the anticholinesterase, neostigmine, into the pontine reticular formation (one of the projection sites for PPT). Third, REM sleep is abolished by lesion of the PPT nucleus but, interestingly, not by lesion of the LDT. 

A catalytic cycle proposed for the metal-phosphine complexes involves the oxidative addition of borane to a low-valent metal yielding a boryl complex (35), the coordination of alkene to the vacant orbital of the metal or by displacing a phosphine ligand (35 —> 36) leads to the insertion of the double bond into the M-H bond (36 —> 37) and finally the reductive elimination to afford a hydroboration product (Scheme 1-11) [1]. A variety of transition metal-boryl complexes have been synthesized via oxidative addition of the B-H bond to low-valent metals to investigate their role in cat-... 

The NO donor, C87-3754, reportedly attenuates the injury induced in cats by splanchnic artery occlusion of the coeliac, superior mesenteric and inferior mesenteric... 

In a percussive brain injury model in cats, N-acetylcysteine (NAG) preserved normal hyperventilation when administered either prior to or 30 min post-insult (Ellis etal., 1991), NAG was also found to be active in a model of acute immunological alveolitis in the rat in... 

Maeda, H. Sato, T. and Maki, S. Effects of dopamine agonists on hypothalamic defensive attack in cats. Physiol Behav 35 89-92, 1985. 

Duarte-Escalante, O., and Ellinwood, E.H., Jr. Central nervous system cytopathological changes in cat with chronic methedrine intoxication. 

---