Drug-induced disorders

Holland, E.G. and DeGruz, F.V (1997). Drug-induced disorders. American Family Physician 56 1781-1788. 

Gatenby, R.A., The radiology of drug-induced disorders in the gastrointestinal tract, Sem. 

The possible drug-induced causes of ANCA-positive vasculitis with high titers of antimyeloperoxidase antibodies in 30 new patients have been reviewed (65). The findings illustrated that this type of vasculitis is a predominantly drug-induced disorder. Only 12 of the 30 cases were not related to a drug. The most frequently implicated drug was hydralazine (n = 10) the remainder involved propylthiouracil (n = 3), penicillamine (n = 2), allopurinol (n = 2), and sulfasalazine (n = 1). 

It is now widely accepted that the term Parkinson s syndrome refers to a collection of neurodegenerative diseases, all of which are characterized by movement disorders. It also applies to drug-induced disorders of the parkinsonian type. A schematic representation of this syndrome is shown in Figure 13.1. 

Complications of drug treatment unwise use of drugs producing adverse effects drug-induced disorder. 

Hahn TJ. Drug-induced disorders of vitamin D and mineral metabolism. Clin Endocrinol Metab 1980 9(l) 107-27. 

From a pharmaceutical care perspective, disorders of electrolyte homeostasis can result from drug therapy. In addition, with some drug therapies, toxicity can be enhanced when underlying electrolyte disorders are present. Drug-induced disorders respond well to... 

Siegel AJ, Baldessarini RJ, Klepser MB, et al Primary and drug-induced disorders of water homeostasis... 

Ivy Sharer. In the case of Ivy Sharer, a diffuse myopathic process was ) superimposed on her AIDS and her pulmonary tuberculosis, either of which could have caused progressive weakness. In addition, she could have been suffering from a congenital mtDNA myopathy, symptomatic only as she ages. A systematic diagnostic process, however, finally led her physician to conclude that her myopathy was caused by a disorder of oxidative phosphorylation induced by her treatment with zidovndine (AZT). Fortunately, when AZT was discontinued, Ivy s myopathic symptoms gradually subsided. A repeat skeletal muscle biopsy performed 4 months later showed that her skeletal muscle cell mtDNA had been restored to normal and that she had experienced a reversible drug-induced disorder of oxidative phosphorylation. 

Akoun, G.M., et al.. Natural history of drug-induced pneumonitis. In Drug Induced Disorders, Volume 3 Treatment Induced Respiratory Disorders (Akoun, G.M., and White, J.P., eds.). New York Elsevier Scientific Publishers B.V., 1989, pp. 3-9. 

Gore RM, Levine MS, Gharemani GG (1999) Drug-induced disorders of the stomach and duodenum. Abdom Imaging 24 9-16... 

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