Impaired lung function

Implications to Humans. Acidic precipitation has not been observed with concentrations that pose a concern to human exposure. The acidic airborne pollutants in the particulate or gaseous forms such as the oxides of sulphur and of nitrogen, and the associated photochemical oxidant ozone, are inhaled. This may lead to the irritation of the respiratory tract, and subsequently to impaired lung function, aggravated asthma and bronchitis. 

Long-term exposure to low levels of nickel carbonyl have been associated with impaired lung function characterized by obstructive pattern and small airway dysfunction. ... 

A number of studies have examined the potential for airborne aluminum to induce respiratory effects in chronically exposed workers. Exposure to aluminum fumes and dust occurs in potrooms where hot aluminum metal is recovered from ore, in welding operations, and the production and use of finely powdered aluminum. Wheezing, dyspnea, and impaired lung function have been observed in potroom workers (Bast-Peetersen et al. 1994 Chan-Yeung et al. 1983 Simonsson et al. 1985). Because these workers were also exposed to a number of other toxic chemicals including sulfur dioxide, polycyclic aromatic hydrocarbons (PAHs), carbon monoxide, and hydrogen fluoride, it is difficult to ascribe the respiratory effects to aluminum. 

Rabbit (NS) 4-6 wk 5 d/wk 6 hr/d Resp 0.6 M (decreased macrophage activity, impaired lung function) Johansson et al. 1986b Cr(N03)39H20(lll)... 

Buster M, Rook L, van Brussel GH, van Ree J, van den Brink W. Chasing the dragon, related to the impaired lung function among heroin users. Drug Alcohol Depend 2002 68(2) 221-8. 

Schwartz DA, Fuortes LJ, Galvin JR, et al. 1990. Asbestos-induced pleural fibrosis and impaired lung function. Am Rev Respir Dis 141 321-326. 

Hallgren, R, Bjermer, L., Lundgren, R and Venge, P. (1989). Tho eosinophil component of the alveolitis in idiopathic pulmonary fibrosis. Signs of eosinophil activation in the lung are related to impaired lung functions. Am. Rev. Respir. Dis. 139, 373-377. 

Ozone is produced as a result of chemical reactions of hydrocarbons and nitrogen oxides in the air in the presence of sunlight. It is a pungent-smelling, faintly bluish gas. Ozone can irritate the respiratory system and impair lung function. Other oxidants that accompany ozone are strong eye irritants. 

ACUTE HEALTH RISKS irritation to skin, eyes, and respiratory tract irritation of mucous membranes iacrimation comeal bums cough sore throat chest pain shortness of breath labored breathing nausea vomiting abdominal pain burning sensation shock or collapse may cause impaired lung function death in high concentrations. 

Metal fume fever has been observed in humans who inhaled high concentrations of zinc oxide fumes. Metal fume fever is believed to be an immune response characterized by increased body temperature, impaired lung function, increased number of leukocytes in the blood, and bronchoalveolar lavage fluid. Similar effects were observed in animals. Metal fume fever has been observed after acute, intermediate, and chronic inhalation exposures to zinc oxide. 

Ozone is a strong oxidant and it can be detrimental to human health at elevated concentrations in the ambient air. Adverse health effects, such as impaired lung function, occur in the population when exposed for several hours at ozone concentrations of 120 ppb. Sensitive people show health effects at substantially lower concentrations. The guidline of the World Health Organization (WHO) for protection of human health effects of ozone in ambient air is approximately 60 ppb for 8 hr. It has been reported that the elevated concentration of ozone for over 70 million people living in the United States still exceeded the National Ambient Air Quality standard (80 ppb for 8 hr) in 1998 despite considerable regulatory efforts to reduce air pollution. 

Because of their impaired lung function, obese people are more at risk of respiratory distress, pneumonia and bronchitis than are lean people, fn addition, excess body weight is associated with increased morbidity from such conditions as ... 

Parvez F, Chen Y, Ytmus M, Olopade M, Segers S, Slavkovich V, et al. Arsenic exposure and impaired lung function findings from a large population-based prospective cohort study. Am J Respir Grit Care Med 2013 188(7) 813-9. 

There are dear and consistent relationships between dust exposure and ventilatory function in smoking and non-smoking coal miners, but dust effect on ventilatory function is independent of the presence or absence of radiological CWP (Coggon and Taylor 1998 Oxman et al. 1993). Particularly, micronodules detected by CT scanning do not, by themselves, have an influence on the pulmonary function, but associated chronic obstructive pulmonary disease, whatever its cause, is the major determinant of the impaired lung function (Collins et al. 1993 Gevenois et al. 1998). 

Gupta, P. Baneijee, D.K. Bhargava, S.K. Kaul, R. Shankar, V.R. 1993. Prevalence of impaired lung function in rubber manufacturing factory workers exposed to... 

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