Immunoglobulins molecular weights

Immunoglobulin Molecular weight (kD) Carbohydrate (%) Valence for antigen binding... 

The heavy chains of each immunoglobulin molecule are identical. Depending on the class of immunoglobulin, the molecular weight of these subunits ranges from about 50,000 to around... 

The basic structure of an immunoglobulin molecule, such as the major serum antibody IgG, consists of four polypeptide chains two identical light chains (molecular weight around 25 000 daltons) and two identical heavy chains (with a molecular weight around 50 000 daltons), cross-linked by disulfide bonds to form Y-shaped molecules with two flexible arms (Fig. 11.2). The binding sites are located on the arms and vary from one molecule to another (variable region) [22b]. 

While many allergens are present in a variety of foods, specific allergens are found only in particular products. Most have a low molecular weight, except for immunoglobulins 9S, Ig M class, from milk. 

This immunoglobulin has a molecular weight of 160,000 with a sedimentation coefiicient of 7 S. It accounts for 70-80% of the total y-globu-... 

Size. Most commonly-used drugs have molecular weights of less than 1000 daltons and their molecular dimensions are small compared with those of the complex lipids and, especially, the proteins of the cell wall. So their size provides little hindrance to crossing cell walls. Molecules as big as moderately-sized proteins (30,000 daltons and above) have much more difficulty in getting across and normally have to be administered directly into the blood stream (e.g., gene transfer, immunoglobulins). 

Antibodies or immunoglobulins (these terms are interchangeable) are glycoproteins which bind specifically to the antigens that induced their formation and each one is formed as a unique response to that particular antigen. In the body they are present in body fluids and certain types of cell. Serum, the fluid that separates when blood is allowed to clot, contains no cells but it does contain the immunoglobulins which can be separated electrophoretically. They have different molecular weights and... 

Antibodies are immunoglobulins, proteins with a molecular weight of 150,000 (IgD, IgG) to 890,000 (IgM), which are synthesized in response to an antigen. There are five classes of... 

Introduction into the body of an alien substance (an antigen) of sufficient molecular weight induces the production of biomolecules called antibodies. Antibodies are glycoproteins, also referred to as immunoglobulins (principally IgG). 

Beh, K. J. 1973. Distribution of brucella antibody among immunoglobulin classes and a low molecular weight antibody fraction in serum and whey of cattle. Res. Vet. Sci. 14, 381-384. 

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