Immunoglobulin class switching

FUNCTION MEDIATES B-CELL PROLIFERATION IN THE ABSENCE OF COSTIMULUS AS WELL AS IGE PRODUCTION IN THE PRESENCE OF IL-4. INVOLVED IN IMMUNOGLOBULIN CLASS SWITCHING. 

Iwasato, T., Shimizu, A., Honjo, T., Yamagishi, H. (1990). Circular DNA is excised by immunoglobulin class switch recombination. Cell 62, 143-149. 

Matsuoka, M., Yoshida, K., Maeda, T., Usuda, S., Sakano, H. (1990). Switch circular DNA formed in cytokine-treated mouse splenocytes evidence for intramolecular DNA deletion in immunoglobulin class switching. Cell 62,135-142. 

Obata, M., Kataoka, T Nakai, S., Yamagishi, H., Takahashi, N., Yamawaki-Kataoka, Y., Nikaido, T., Shimizu, A., Honjo, T. (1981). Structure of a rearranged yl chain gene and its implication to immunoglobulin class-switch mechanism. Proc. Natl. Acad. Sci. USA 78,2437-2441. 

Harriman, W., Volk, H., Defranoux, N. and Wabl, M. (1993). Immunoglobulin class switch recombination. Annu. Rev. Immunol. 11, 361-384. 

Von Schwedler V, Jack HM, Wabl M Circular DNA is a product of the immunoglobulin class switch rearrangement. Nature 1990 345 452 156. 

Ehrenstein, M. R., and Neuberger, M. S. (1999). Deficiency in msh2 affects the efficiency and local sequence specificity of immunoglobulin class-switch recombination parallels with somatic hypermutation. EMBO J. 18, 3484—3490. 

Imai, K., Slupphaug, G., Lee, W. I., Revy, P., Nonoyama, S., Catalan, N., Yel, L., Forveille, M., Kavli, B., Krokan, H. E., Ochs, H. D., Fischer, A., and Durandy, A. (2003b). Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination. Nat. Immunol. 4, 1023-1028. 

Kinoshita, K., Lee, C., Tashiro, J., Muramatsu, M., Chen, X., Yoshikawa, K., and Honjo, T. (1999). Molecular mechanism of immunoglobulin class switch recombination. Cold Spring Harb. Symp. Quant. Biol. 64, 217-226. 

Yu, K., and Lieber, M. (2003). Nucleic acid structures and enzymes in the immunoglobulin class switch recombination mechanism. DNA Repair 1163-1174. 

Sugai M, Kondo S, Shimizu A, Honjo T (1998) Isolation of differentially expressed genes upon immunoglobulin class switching by a subtractive hybridization method using uracil DNA glycosylase. Nucleic Acids Res 26 911-918. 

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