Immunogens hemagglutinin

Measles virus hemagglutinin (H) protein Carrot leaf and root IgGl and IgG2 cross reacted strongly with measles virus and neutralized virus in vivo. Immunogenic in mice when delivered parenterally. 39... 

The latter approach has been followed in our laboratory. For instance, in studies related to the synthesis of potent multivalent sialoside inhibitors of influenza virus hemagglutinin [34], it became of interest to evaluate the immunogenicity of neoglycoproteins containing sialosides as sole immunodominant hapten. To this end, acetochloroneuraminic acid (1) was transformed into allyl glycoside 2 (Scheme 1) which upon reductive ozonolysis afforded aldehyde 3 in excellent overall yields [35], Reductive amination of 3 to bovine serum albumin (BSA) and tetanus toxoid provided immunogenic vaccines from which specific rabbit IgG anti-sialic acid antibodies were obtained [36]. In order... 

Hinds et al.[26 used a helicogenic Ca-alkylproline derivative 271 in the peptide Ac-Tyr-Pro-Tyr-Asp-Val-Pro-Asp-Tyr-Ala-OH, which is derived from an immunogenic sequence in influenza hemagglutinin, specifically replacing the first Pro residue in the sequence. They found increased binding to a pair of monoclonal antibodies which recognize this site. 26 The insertion of C -alkyl a-amino acids into peptide systems is discussed in Section 10.3. 

Seth A, Yasutomi Y, Jacoby H, Callery JC, Kaminsky SM, Koff WC, Nixon DF, Letvin NL (2000) Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals. AIDS Res Hum Retroviruses 16(4) 337-343 Shahin RD, Amsbaugh DF, Leef MF (1992) Mucosal immunization with filamentous hemagglutinin protects against Bordetella pertussis respiratory infection. Infect Immun 60(4) 1482-1488... 

See Nossal, 2003, note 64 E. Marquet-Blouin et al., Neutralizing immunogenicity of transgenic carrot (Daucus carota L.)-derived measles vims hemagglutinin, Plant Molecular Biology, 51, 2003, 459-69. 

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