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Filamentous hemagglutinin

Clantin, B., Hodak, H., Willery, E., Locht, C., Jacob-Dubuisson, F., and Villeret, V. (2004). The crystal structure of filamentous hemagglutinin secretion domain and its implications for the two-partner secretion pathway. Proc. Natl. Acad. Sci. USA 101, 6194-6199. [Pg.91]

Seth A, Yasutomi Y, Jacoby H, Callery JC, Kaminsky SM, Koff WC, Nixon DF, Letvin NL (2000) Evaluation of a lipopeptide immunogen as a therapeutic in HIV type 1-seropositive individuals. AIDS Res Hum Retroviruses 16(4) 337-343 Shahin RD, Amsbaugh DF, Leef MF (1992) Mucosal immunization with filamentous hemagglutinin protects against Bordetella pertussis respiratory infection. Infect Immun 60(4) 1482-1488... [Pg.221]

Filamentous hemagglutinin and recombinant pertussis toxin (single or bivalent vaccine) Chitosan stimulates mucosal and systemic effects 209,210... [Pg.636]

An overview of clinical trials with a special diphtheria and tetanus toxoids and acellular pertussis (DTaP) vaccine has been published (3). The vaccine contains as pertussis components purified filamentous hemagglutinin, pertactin, and genetically engineered pertussis toxin. The vaccine induces high and long-lasting immunity and is at least as efficacious as most whole-cell pertussis vaccines and similar in efficacy to the most efficacious acellular... [Pg.2783]

Acellular pertussis vaccines contain selective components of the B. pertussis organism. All acellular vaccines contain pertussis toxin (PT), and some contain one or more additional bacterial components (e.g., filamentous hemagglutinin [FHA], pertactin [a 69-kDa outer membrane protein], and fimbriae types 2 and 3). Acellular pertussis vaccine is recommended for all doses of the pertussis schedule at 2, 4, 6, and 15 to 18 months of age. A fifth dose of permssis vaccine is given to children 4 to 6 years of age. Pertussis vaccine is administered in combination with diphtheria and tetanus (DTaP). Although the permssis vaccine is not recommended for individuals 7 years of age and older, booster doses for adolescents and adults may be incorporated into future recommendations because members of these groups are important reservoirs of infection. [Pg.2240]

DIPHTHERIA AND TETANUS TOXOIDS AND ACELLULAR PERTUSSIS ADSORBED, HEPATITIS B (RECOMBINANT) AND INACTIVATED POLIOVIRUS VACCINE COMBINED (Pediarix injection 25 Lf diphtheria toxoid, 10 Lf tetanus toxoid, 25 meg inactivated pertussis toxin (PT), 25 meg filamentous hemagglutinin (FHA), 8 meg pertactin,... [Pg.206]

Berggard K, Johnsson , Mooi FR et al. Bordetella pertussis binds the human complement regulator C4BP role of filamentous hemagglutinin. Infect Immun 1997 65 3638-3643. [Pg.48]

Most current whooping cough vaccines are inactivated whole B. pertussis. The cells are harvested by centrifugation and then resuspended in buffer, which is the supemate in some cases. This is done because some of the filamentous hemagglutinin (FHA) and pertussis toxin (PT) antigens are released into the supernate. The cell concentrate is inactivated by mild heat and stored with thimerosal and/or formaldehyde. The inactivation process serves the dual purpose of killing the cells and inactivating the toxins. [Pg.206]

See other pages where Filamentous hemagglutinin is mentioned: [Pg.56]    [Pg.94]    [Pg.203]    [Pg.206]    [Pg.217]    [Pg.1137]    [Pg.2784]    [Pg.2784]    [Pg.3325]    [Pg.3325]    [Pg.491]    [Pg.500]    [Pg.1421]    [Pg.40]    [Pg.593]    [Pg.206]   
See also in sourсe #XX -- [ Pg.491 ]



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