Immunoblastic lymphadenopathy

Hypersensitivity reactions are relatively common with carbamazepine. Most affect the skin, but systemic reactions with fever, lymphadenopathy, and/or involvement of the bone-marrow, the liver, the heart, the gastrointestinal system, the lungs, and other organs have been described. Severe serum sickness associated with immunoblastic lymphadenopathy has been reported in one case (SED-13, 148) (64). Occasional cases of systemic lupus erythematosus have occurred within the first few months, although an unusual case with onset after 8 years has been described (SEDA-22, 83). 

There have been individual reports of fatal angio-immunoblastic lymphadenopathy, hemolytic uremic syndrome (after typhoid/paratyphoid/diphtheria vaccination), fatal hyperpyrexia (SED-11, 687), transverse myelitis (SEDA-10, 288), erythema nodosum (SEDA-11,289) (SEDA-14, 281), and Reiter s sjmdrome (SEDA-15, 350). 

Kreisler JM, Moreno E, Moneo I et al. (1977) Immunological findings in immunoblastic lymphadenopathy. A detailed case study. Clin Exp Immunol 27 497-501 Liskow B, Liss JL, Parker CW (1971) Allergy to marihuana. A case report. Ann Intern Med 75 572... 

Lymphadenitis mimicking Hodgkin disease has been described as a benign lymphadenopathy that can mimic interfollicular HL.11 420 Cervical lymph nodes are affected most often. There is no progression to lymphoma. The lymph nodes show follicular hyperplasia with a mottled interfollicular zone with epithelioid histiocytes, lymphocytes, eosinophils, and immuno-blasts. Some immunoblasts with prominent nucleoli resemble H/RSCs. However, their nucleoli are typically smaller and basophilic, in contrast to the eosinophilic nucleoli of H/RSCs. Immunohistochemistry distinguishes this disorder from interfollicular HL because... 

Angioimmunoblastic lymphadenopathy (AIBL) can involve the lung in the form of diffuse interstitial infiltrates. Typically, there is little difficulty in distinguishing AIBL from LIP since AIBL has a distinctive set of clinical features, including generalized lymphadenopathy, hepatosplenomegaly, Coombs-positive hemolytic anemia, and skin rash. Microscopically, AIBL is polymorphous but includes numerous atypical immunoblasts as well as lymphocytes and plasma cells. The cellular infiltrate also predominantly involves lymphatic routes (around airways and vessels), rather than the interstitial compartment, as in the case of LIP (69). 

---