Immune response Treg cells

The Th-1 /Th-2 paradigma forms a core mechanism regulating the nature of an immune response. More recently, this concept was further developed by identifying Th-subsets with predominantly suppressing properties, T-regulatory cells (Treg). These cells also play a major role in keeping those cells at rest, which have escaped central tolerance (peripheral self tolerance). 

These experiments also make another important point, namely that it is apparently never too late to interfere with an immune response by Treg suppression since the experiments show that suppression can affect fully differentiated effector cells. This is good news in the sense that the obviously effective suppression late during an immune response can revert rather than prevent unwanted immunity, a concept that may become extremely useful in the clinic. 

Treg cells not only prevent undesired immune responses to innocuous antigens applied onto the skin, but also promote the termination of ongoing... 

The hypothesis of the existence of T cells that specifically regulate immune responses towards self and allogeneic antigens has been formulated since 25 years ago [21]. However, phenotype and functional properties of Treg have been at least partially defined only in the last few years. 

Importantly, although Th2 cells are responsible for the development of allergic diseases, Thl cells may contribute to chronicity and effector phase in allergic diseases [30-33,38,39]. Distinct Thl and Th2 2 subpopulations of T cells counterregulate each other and play a role in distinct diseases [34,35]. In addition, recent studies have demonstrated that peripheral T-cell tolerance is crucial for a healthy immune response and successful treatment of allergic disorders [40-42]. A further subtype ofT cells, with immunosuppressive function and cytokine profiles distinct from either Thl and Th2 cells, termed regulatory/suppressor T cells (Treg), has been existence in humans has been demonstrated [41,... 

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