Immune-regulatory activities

Read S, Mauze S, Asseman C, Bean A, Coffman R, Powrie F CD384-CD45RBI CD4+ T ceUs a population of T ceUs with immune regulatory activities in vitro. Eur J Immunol 1998 28 3435-3447. 

Renga B, Mencarelli A, Cipriani S, et al. The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal... 

Although the stratum corneum acts as a simple physical barrier to outside influences, skin tissue as a whole is very active. It is crucial in maintaining the body s homeostasis, its essential steady-state environment. Skin maintains temperature and balance of electrolytes, the dissolved salts in internal body fluids. It is metabolically active and participates in hormonal and immune regulatory processes. More than serving as a passive barrier, it is proactive in response to xenobiotic insults and can be damaged in the defensive process by developing rashes and other symptoms. 

Colonization with helminths prevent onset of diabetes in the NOD murine model of TID. NOD mice exposed to S. mansoni are protected from developing diabetes. Schistosome egg or antigen e q>osure induces immune regulatory ILIO and augments NKT cell activity that may help prevent insulinitis. Colonization with T. spiralis or H. polygyrus also inhibits diabetes in NODmice. ... 

Leukotrienes and Prostanoids. Arachidonic acid (AA) (213) and its metabohtes are iavolved ia cellular regulatory processes ia all three principal chemical signaling systems endocrine (see Hormones), immune, and neuronal (62). FoUowiag receptor activation or iacreased iatraceUular... 

Immune complex enhancement. Beta-cells activation and Increased insulin production (Btuni, 1988). Neuro-regulatory effect (Nakazawa et al., 1977 Btuni, 1988 Hiraga et al., 1993). 

A recent report has demonstrated that the proteolytic activity of NS3 plays an additional role in viral infection, beyond polyprotein processing. An important mediator of the cellular immune response is the transcription factor interferon regulatory factor 3 (IRF-3), which becomes activated on infection and then stimulates production of type-1 interferon and other antiviral genes [46]. It was found that expression of heterodimeric NS3/4A... 

---