Immune-mediated glomerular disease

Immme-Mediated Glomerular Disease Animal models have been crucial to the understanding of immune-mediated glomerular disease in humans. Several animal models have developed using injection of preformed antibodies to... 

In rats, particularly Brown Norway rats, D-penicillamine induces a disease characterized by dermatitis, vasculitis, production of antinuclear antibodies, formation of circulating immune complexes, and IgG deposits along the glomerular basement membrane (Donker et al., 1984 Toumade et al., 1990). In D-penicillamine-treated Brown Norway rats, a preferential increase in IgE mediated by IL-4 was observed as well, and this suggested that D-penicillamine preferentially stimulates Th2 cells. Interestingly, low-... 

While previous studies have focused on MPO in cardiovascular disease, it is important to consider the role of monocytes, macrophages, eosinophils, and neutrophils as mediators of innate immunity, and as important responsive cells in inflammation. The role of MPO and EPO and their hypohalous acids targeting lipids to generate novel halogenated lipids is relatively unexplored, and should be thoroughly examined, in diseases including pancreatitis, asthma, renal glomerular, and tubular disease. 

Kalluri R, Danoff TM, Okada H, et al. Susceptibility to anti-glomerular basement membrane disease and Goodpasture syndrome is linked to MHC class II genes and the emergence of T cell-mediated immunity in mice. J CUn Invest 1997 100(9) 2263-2275. 

Hopfer H, Maron R, Buztmann U, et al. The importance of cell-mediated immunity in the course and severity of autoimmune anti-glomerular basement membrane disease in mice. FASEB J 2003 17 860-868. 

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