Imaging applications disease

Quantum dots have many promising applications in diode lasers [8], QD-LED for computer displays [9], quantum computing [10], solar cells [11], and biological applications such as medical imaging and disease detection [12]. 

Application of Protein Imaging to Disease Model Mice One of the advantages of traditional MS, including both MALDI- and ESI-MS, is that they can distinguish even slight structural variations of analyte molecules by their masses. Due to this unique advantage, MS has frequently been applied to the identification/ characterization of posttranslational modifications in modern proteome researches [12]. In this context, IMS also enables the distinct detection of the protein molecular species as well as the visualization of the distribution of these species on the tissue sections. As an excellent example, in the Stoeckli et al. study, amyloid... 

Nanomedicine is a broad scientific area that spans the areas of biology, medicine, chemistry, and engineering. It aims to use nanoscale platforms for the detection and treatment of cancer and other diseases with high sensitivity and improved outcome [6, 9,10]. Improvements in imaging applications, multi-valent tissue-specific binding, redirection of the biodistribution of drugs, and reduced toxicity of chemotherapeutics... 

Over the last 10 years there has been a major initiative to bring HTS into the academic community. The NIH roadmap has a mission to build a better toolbox for medical research in the twenty-first century and to empower the research community to use small molecule compounds in their research, whether as tools to perturb genes and pathways, as imaging probes in basic or clinical applications, or as starting points to the development of new therapeutics for human disease. 

Stauber J, Lemaire R, Franck J, et al. MALDI imaging of formalin-fixed paraffin-embedded tissues application to model animals of Parkinson disease for biomarker hunting. J. Proteome Res. 2008 7 969-978. 

The immobilisation of proteins into inorganic mesoporous host materials has attracted considerable attention due to the potential applications in biochemical, biomedical, industrial and bio-analytical fields [1] Biocompatible supports endowed with fluorescent tracers and adequately modified for specific interactions with cellular antigens are an amenable tool for image in living cells processes that are relevant to diseases. 

Brain infarction was the first clinical application of SPECT. Decreases in relative cerebral perfusion were imaged by SPECT for diagnosis. Decreased rCBF is visualized in the form of decreased signal on SPECT and PET. The sensitivity and specificity of brain SPECT for infarct localization are 85.5% and 97.6%, respectively [99]. Blood-flow imaging is useful in the evaluation of response to therapy in patients with cerebrovascular diseases [100]. 

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