I gene

RIICHIRO SAITO.i GENE DRESSELHAUS2 and MILDRED S. DRESSELHAUS3... 

Tachykinin 1 gene TAC1. PPT-A. PPT-i Preprotachykinin A gene, Preprotachykinin I gene... 

The proline transport protein prnB of Aspergillus nidulans [47] is very similar to the above-mentioned family of Saccharomyces cerevisiae amino acid transporters (about 42% identity with the PUT4 gene product and 30% identity with the CANl and the HIP I gene products). So is the AroP general aromatic amino acid transporter protein of Escherichia coli K-12, which has about 30% identity with the HIPI gene product [48]. Both hydrophilic ends are very different from one transporter to another (see Fig. 2). 

B34. Brady, H. J. M., Sowden, J. C Edwards, M., Lowe, N., and Butterworth, P. H. W Multiple GF-1 binding sites flank the erythroid specific transcription unit of the human carbonic anhydrase I gene. FEBS Lett. 257,451-456 (1989). 

Okamoto, M., Bessho, Y., Kamiya, M., Kurosawa, T. and Horii, T. (1995) Phylogenetic relationships within Taenia taeniaeformis varian Is and other taeniid cestodes inferred from the nucleotide sequence of the cytochrome c oxidase subunit I gene. Parasitology Research 81, 451-458. 

Chen, S.H., Zhou, S.H., Sarkar, M., Spence, A.M. and Schachter, H. (1999) Expression of three Caenorhabditis elegans A-acetyl gl ucosam i n yl trail sft rase I genes during development. Journal of Biological Chemistry 274, 288-297. 

The three class I ADH promoters are very similar. Prominent among the ds-act-ing elements that contribute to promoter function are the TATA box, a pair of C/ EBP sites (that can also be bound by DBP) flanking the TATA box, an E-box sequence (CACGTG) just upstream at which USF can bind, and a G3T sequence (that binds Spl) one helical turn further upstream from the E-box [28, 29]. Further upstream are CTF/NF-1 and HNF-1 sites, and some elements that are specific to only some of these genes [24]. Differences among the class I genes in these and other sites affect the tissue distribution and amount of expression. Sequence differences among individuals could well affect the level and site(s) of expression, and thereby the effects of alcohol. 

Yanagawa Y, Chen JC, Hsu LC, Yoshida A. The transcriptional regulation of human aldehyde dehydrogenase I gene. The structural and functional analysis of the promoter. J Biol Chem 1995 270 17521-17527. 

Huynh HT, Poliak M (1993) Insulin-like growth factor I gene expression in the uterus is stimulated by tamoxifen and inhibited by the pure antiestrogen ICI 182780. Cancer... 

J. C. Walker, E. A. Howard, E. S. Dennis, W. J. Peacock (1987) DNA sequences required for anaerobic expression of the maize alcohol dehydrogenase I gene. Proc. Natl. Acad. Sci. USA, 84 6624-6628... 

Acetylation mediated by NAT2 was one of the first metabolic pathways found to be polymorphic. The rapid and slow phenotypes are approximately equal in prevalence in North America, whereas about 90% of Orientals exhibit the rapid acetylator phenotype while the ratio is reversed in people of Middle Eastern decent. Although the NAT I gene is also polymorphic, the corresponding phenotype is not as clear. 

Wood LJ, Maher JF, Bunton TE, Resar LM (2000a) The oncogenic properties of the HMG-I gene family. Cancer Res 60(15) 4256-4261... 

In addition, the i gene, which encodes the lac repressor protein, is also considered part of the operon although it is located at a distant site in the DNA. The i gene is constitutively expressed (not regulated) thtis, copies of the lac repressor protein are always in the cell. 

The lac repressor (encoded by the i gene), vdiidi binds to a DNA sequence called the operator... 

Silverman, T., Rein, A., Orrison, B., Langloss, J., Bratthauer, G., Miyazaki, J., andOzato, K. (1988) Establishment of cell lines from somite stage mouse anbryos and expression of major histocompatibility class I genes in these cells. J. Immunol. 140,4378-4387. 

A. OTC is a metabolic enzyme required to break down ammonia. Total lack of this enzyme leads to death shortly after birth owing to a buildup of ammonia. The partial presence of OTC also leads to accumulation of ammonia, which can be controlled by drugs and dietary intake. The genetic cause of this disease, its morbidity, and the need for rapid production of OTC by adenoviral vectors may extend the life span of OTC-deficient newborns to allow for drug treatment and dietary manipulation. Jesse Gelsinger, the 18-year-old patient who was the first patient to die on a phase I gene therapy trial, had OTC deficiency. 

Johnson DW, Berg JN, Baldwin MA et al. Mutations in the activin receptor-like kinase I gene in hereditary haemorrhagic telangiectasia type 2. Nat. Genet. 13, 189-195, 1996. 

Newcomb, R.D. and Gleeson, D.M. (1998). Pheromone evolution within the genera Ctenopseustis and Planotortrix (Lepidoptera Tortricidae) inferred from a phylogeny based on cytochrome oxidase I gene variation. Biochemical Systematics and Ecology 26 473 184. 

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