Hypoxia-induced factor

Zagzag D, Lukyanov Y, Lan L, Ah MA, Esencay M, Mendez O, Yee H, Voura EB, Newcomb EW (2006) Hypoxia-inducible factor 1 and VEGF upregulate CXCR4 in glioblastoma implications for angiogenesis and glioma cell invasion. Lab Invest 86 1221-1232... 

Ahn JK, Koh EM, Cha HS, Lee YS, Kim J, Bae EK (2008) Role of hypoxia-inducible factor-lalphain hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-tike synoviocytes. Rheumatology (Oxford) 47(6) 834-839 Ao X, Wang X, Lennartz MR, Loegering DJ, Stenken JA (2006) Multiplexed cytokine detection in microUter microdialysis samples obtained from activated cultured macrophages. J Pharm Biomed Anal 40(4) 915-921... 

Zhou YD et al (2005) Terpenoid tetrahydroisoquinoline alkaloids emetine, king me. and isocephae-line inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells. J Nat Prod 68(6) 947-950... 

P. Frohna, S. Milwee, J. Pinkett, T. Lee, K. Moore-Perry, J. Chou, and R. H. Ellison in Results from a Randomized, Single-Blind, Placebo-Controlled Trial of FG-4592, a Novel Hypoxia Inducible Factor Prolyl Hydroxylase Inhibitor, in CKD Anemia, Vol. 2007, American Society of Nephrology Renal Week, San Francisco, November 2-5, 2007, Abstract SU-PO806, as abstracted in N. Agarwal and J. T. Prchal, Semin. Hematol., 2008, 45, 267. 

EPSP excitatory postsynaptic potential HIF hypoxia-inducible factor... 

TF transcription factor, R receptor, Fur ferric uptake regulation protein, NF-kB nuclear factor-kB, AP-1 activator protein-1, Egr-1 early growth response-1, VDR la,25-dihydroxy-vitamin D3 receptor, RXR retinoid X receptor, PPARy peroxisome proliferator-activated receptor y NFAT nuclear factor of activated T-cells, HSF heat shock factor, p53 tumor suppressor p53, HIF-1 hypoxia inducible factor-1. ... 

Diabetes is hypothesized to cause cardiac protein acetylation and the acetylation alters the protein function (Fig. 3b). Hypoxia-inducible factor-1 (HIFl) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. Diabetes interferes with cellular response to hypoxia. In hyperglycemic conditions HIFl degradation is increased because of enhanced HIFl acetylation by... 

Siddiq, A., Ayoub, I.A., Chavez, J.C., et al. (2005) Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J. Biol. Chem., 280,41732-41743. 

Thomas GV, Tran C, MelUnghoff IK, Welshie DS, Chan E, Fueger B, Czemin J, Sawyers CL. (2006) Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 12 122-127. 

Recent studies have demonstrated that overexpression of HDACl represses the tumor suppressors, p53 and von Hippel-Lindau (VHL), but induces the hypoxia-responsive genes, hypoxia inducible factor alpha (HIF-la) and vascular endothelial growth factor (VEGF) and increases angiogenesis. Conversely, HDAC inhibitors derepress the tumor suppressors, p53 and VHL, and repress HIF-la and VEGF [68, 69]. 

Qian, D.Z., Kachhap, S.K., Collis, S.J., Verheul, H.M., Carducci, M.A., Atadja, P. and Pili, R. (2006) Class 11 histone deacetylases are associated with VHL-independent regulation of hypoxia-inducible factor 1 alpha. Cancer Research, 66, 8814-8821. 

Keith B, Simon MC (2007) Hypoxia-inducible factors, stem cells, and cancer. CeU 129 465 72... 

Benita Y, Kikuchi H, Smith AD et al (2009) An integrative genomics approach identifies hypoxia inducible factor-1 (HIF-1 )-target genes that form the core response to hypoxia. Nucleic Acids Res 37 4587-4602... 

Lu X, Kang Y (2010) Hypoxia and hypoxia-inducible factors master regulators of metastasis. Clin Cancer Res 16 5928-5935... 

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