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Master regulators

The lac repressor monomer, a chain of 360 amino acids, associates into a functionally active homotetramer. It is the classic member of a large family of bacterial repressors with homologous amino acid sequences. PurR, which functions as the master regulator of purine biosynthesis, is another member of this family. In contrast to the lac repressor, the functional state of PurR is a dimer. The crystal structures of these two members of the Lac I family, in their complexes with DNA fragments, are known. The structure of the tetrameric lac repressor-DNA complex was determined by the group of Mitchell Lewis, University of Pennsylvania, Philadelphia, and the dimeric PurR-DNA complex by the group of Richard Brennan, Oregon Health Sciences University, Portland. [Pg.143]

HIF as master regulator of hypoxia responsive gene expression... [Pg.124]

Dussault I, Forman BM (2002) The nuclear receptor PXR A master regulator of homeland defense. Crit Rev Eukaryot Gene Expr 12 53-64... [Pg.415]

Lu X, Kang Y (2010) Hypoxia and hypoxia-inducible factors master regulators of metastasis. Clin Cancer Res 16 5928-5935... [Pg.249]

Garofalo M, Croce CM (2011) microRNAs master regulators as potential therapeutics in cancer. Annu Rev Pharmacol Toxicol 51 25 3... [Pg.364]

Schal, C., Holbrook, G. L., Bachmann, J. A. S. and Sevala, V. L. (1997). Reproductive biology of the German cockroach, Blattella germanica juvenile hormone as a pleiotropic master regulator. Archives of Insect Biochemistry and Physiology 35 405 126. [Pg.243]

Herwig, S. Strauss, M. (1997) The retinoblastoma protein a master regulator of cell cycle, differentiation and apoptosis. Eur. J. Biochem. 246, 581-601. [Pg.477]

Specific regulator Master regulator of of Tdc TIA biosynthetic genes ... [Pg.118]

A master regulator of cell cycle progression Coefficient of variation Cytosome to vacuole targeting... [Pg.6]

Basu A, Krady JK, Levison SW (2004) Interleukin-1 A master regulator of neuroinflammation. J Neurosci Res 78 151—156. [Pg.491]

Hinnebusch AG, Natarajan K. 2002. Gcn4p, a master regulator of gene expression, is controlled at multiple levels by diverse signals of starvation and stress. Eukaryot Cell 1 22-32. [Pg.266]

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See also in sourсe #XX -- [ Pg.188 , Pg.191 ]



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