Hypotensive alkaloid

The reduction of Woodward s lactone with Saccharomyces cerevisiae produced an intermediate which is used for the preparation of hypotensive alkaloids (equation 44)118. 

In the first synthesis of the hypotensive alkaloid (-)-ephedradine A 3 (Tetrahedron 2004,60, 9615), Tohru Fukuyama of the University of Tokyo faced the challenging of constructing the central five-membered ring ether with control of relative and absolute configuration. While neither chiral Rh catalysts nor chiral auxiliaries alone gave satisfactory results, a combination of the two worked efficiently, yielding the two trans diastereomers of 2 in a 13 1 ratio. 

A new dimeric hypotensive alkaloid has been reported from Hunteria eburnea Pichon (29). Hunteriamine, C39H48N4O2 CH2 was amorphous and gave crystalline salts (perchlorate, mp 279°-281° decomp. [a]jj -1-29° in MeOH pif 6.50 hydrochloride, mp 310°-315° decomp. [a]p -f27° in MeOH pA 6.56 hydroiodide, mp > 300°). The alkaloid has a UV-spectrum typical of a 2,3-dialkyl-5-hydroxyindole and a bathochro-mic shift was observed in base. In the IR-spectrum OH/NH bands were... 

Many other bisben2ylisoquinoliae alkaloids, such as tetrandriae (80), from Cjcleapeltata Hook., are also known. Compound (80), for example, although it causes hypotension and hepatotoxicity ia mammals, ia other tests, possessed enough anticancer activity to be considered for preclioical evaluation (55). The arrow poison tubocurare prepared from Chondrendendron spp. also contains the bisben2yhsoquiQoline alkaloid tubocurariae (9). 

Of the alkaloids of the han-fang-chi group of drugs (p. 350), Ohta states that kukoline is a strong reflex and spasm stimulant and finally causes paralysis and death. Raymond-Hamet states that it suppresses the hypotensive action of dihydroxyphenylethanolethylamine. 

Raymond-Hamet has given much attention to the action of the Rauwolfia alkaloids. Using Siddiqui s ajrhalinine, he found that it provokes hypotension accompanied by renal dilatation and exerts a true sympathi-colytic action. 1 Ajmaline and serpentine also induce hypotension and a decrease in intestinal action serpentinine diminishes the renal constrictive action of adrenaline, but does not alter its hypertensive effects. ... 

Picrasma crenata. Stated to contain an uncharacterised alkaloid sigmine, which lowers the contractility and tonicity of the isolated duodenal preparation of the rabbit. In dogs it is hypotensive and lowers concentration of blood sugar, 3 to 4 hours after injection. (Pereira, Ann. foe. med. Univ. S. Paulo, 1938, 14, 269 Chem. Abstr., 1939, 33, 3877).)... 

Evodiamine, the alkaloid from the Chinese drug plant Evodia rutaecarpa Benth. and Hook., has also been called rhetsine and its oxidation product rhetsinine, which is also found in nature, was shown to be the diamide (53). Recently a hypotensive red alkaloid isolated from the Brazilian plant Hortia arborea Engl, was given the name hortiamine. Degradation and synthetic studies have shown it to possess the structure (55). It was found together with another... 

RISK FDR INJURY. Narcotics may produce orthostatic hypotension, which in turn results in dizziness. The nurse should assist the patient with ambulatory activities and with rising slowly from a sitting or lying position. Miosis (pinpoint pupils) may occur with the administration of some narcotics and is most pronounced with morphine, hydro mo rpho ne, and hydrochlorides of opium alkaloids. Miosis decreases the ability to see in dim light. The nurse keeps the room well lit during daytime hours and advises the patient to seek assistance when getting out of bed at night. 

During the course of a short and efficient total synthesis of (-) -dendrobine (3-76), an alkaloid which exhibits antipyretic and hypotensive activities [37], a new domino radical sequence has been exploited by Cassayre and Zard which involves the cycli-... 

The pyrrolizidines and indolizidines are a group of alkaloids that are characterized by the presence of the basic azabicyclo[3.3.0]octane and azabicyclo[4.3.0]nonane frameworks, respectively. These alkaloids exhibit remarkably diverse types of biological activity and have been reported to act as antitumor, hypotensive, anti-inflammatory, carcinogenic, or hepatoxic agents. Various pyrrolizidines and indolizidines have been prepared by 1,3-dipolar cycloaddition.115 Synthesis of these is described in the section 8.2 discussing cycloaddition. 

O-acyl derivatives thereof have shown potent vasodilatory activity [8]. A number of other hetisine alkaloids have shown diverse biological activities. These include nominine [9] (1) (local anesthetic, anti-inflammatory, and antiarrhythmic), hetisine [9a] (4) (hypotensive), ignavine [10] (5) (analgesic, anti-inflammatory, antipyretic, sedative, antidiuretic), zeravshanisine [9a] (8) (antiarrhythmic and local anesthetic), and tadzhaconine [9a, 11], (9) (antiarrhythmic) (Chart 1.3). 

Lung Cancer Etoposide (VP-16) -plant alkaloid, topoisomerase II inhibitor -bone marrow suppression -nausea and vomiting -mucocutaneous effects (mucositis, stomatitis)—increased at higher doses -chemical phlebitis common -hypotension with rapid administration -hypersensitivity reactions -secondary leukemia... 

Muscarine, an alkaloid from certain species of mushrooms, is a muscarinic receptor agonist. The compound has toxicologic importance muscarine poisoning will produce all of the effects that are associated with an overdose of ACh (e.g., bronchocon strict ion, bradycardia, hypotension, excessive salivary and respiratory secretion, and sweating). Poisoning by muscarine is treated with atropine. 

Wu, W. N., Beal, J. L. and Doskotch, R. W. 1977. Alkaloids of Thalictrum. XXII. Isolation of alkaloids with hypotensive and antimicrobial activity from Thalictrum revoltum. Lloydia, 40 508-514. 

The total synthesis of litseaverticillols D, F and G (172 and 173), which are natural products with anti-HIV activity, was achieved recently via a singlet oxygen initiated cascade proposed to be biomimetic (Scheme 64). Finally, allylic alcohols 174a and 174b (Scheme 64) were isolated in a 4/1 ratio via a stereoselective singlet oxygen ene reaction. Stereoisomer 174a is an intermediate in the synthetic route of staurosporine, which is a bioactive alkaloid with hypotensive, antimicrobial and cell cytotoxic properties. 

N.A. Alkaloids, tannins, saponins, pectin, oleoresin, aldehydes, dimeric indole alkaloids, vinblastine, sesquiterpenes.100114315 Treat diabetes, leukemia, reduce blood pressure, Hodgkin s disease, hypotensive, sedative and tranquillizing, anticancer. 

In 1918 the traditional Indian remedy rauwolfia was reported to be useful in the treatment of hypertension. Reexamination of this material led to the isolation of reserpine (28 R1 = Me, R2 = 3,4,5-trimethoxybenzoyl) which was shown in 1952 to have hypotensive and tranquilizing effects. Other alkaloids such as deserpidine (28 R1 = H, R2 = 3,4,5-trimethoxybenzoyl) and rescinnamine (28 R1 = Me, R2 = 3,4,5-trimethoxycinnamoyl) were later isolated. They are useful when alternative, more potent drugs are not well tolerated. 

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