Hortia arborea

There are several alkaloids in the structure of which are both quinazoline and indole nuclei. Evodiamine (1001 R = H) and rutaecarpine (1002) were both isolated from the seeds of Evodia rutaecarpa about 1916 and synthesized in 1927. They were found subsequently to occur also in Xanthoxylum rhetsa, which in addition yielded rhetsinine (1001 R = OH) (59T(7)257). The plant Hortia arborea afforded two more related alkaloids, hor-tiacine and hortiamine, each characterized by a methoxy group in the benzene ring of the indole portion (60JA5187). 

Evodiamine, the alkaloid from the Chinese drug plant Evodia rutaecarpa Benth. and Hook., has also been called rhetsine and its oxidation product rhetsinine, which is also found in nature, was shown to be the diamide (53). Recently a hypotensive red alkaloid isolated from the Brazilian plant Hortia arborea Engl, was given the name hortiamine. Degradation and synthetic studies have shown it to possess the structure (55). It was found together with another... 

Hortiamine, which can lower blood pressure, is a red alkaloid and the major hypotensive component of the bark of the Brazilian plant Hortia arborea (Rutaceae). Chemically, it is 10-methoxy-14-methyl-5-oxo-5,7,8,14-tetrahydroindolo[2, 3 3,4]pyrido[2,l-6]quinazoline.43 When boiled with moist benzene it forms a yellow product, hydrated as shown in 44, and Amaxfalls from 411 nm to 375 nm. The anhydrous form is regenerated on gentle drying.71... 

Rutaecarpine Evodia rutaecarpa, Hortia arborea Inactive as VAN-R antagonist... 

Rutaecarpine (Ranunculaceae) Evodia rutaecarpa, Hortia arborea COX-2 [AI]... 

H. robustum Hortia arborea Lunasia amara Blanco Melicope fareana Engl. 

The Alkaloids of Hortia arborea Engl. J. Amer. Chem. Soc. 82, 5187... 

Evodia rutaecarpa Hook. f. Thoms. (10, 111, 209) Hortia arborea Engl. (151)... 

A hypotensive red alkaloid isolated from the Brazilian plant Hortia arborea England was called hortiamine. One of the most potent nonprotein neurotoxin tetrodotoxin was isolated from certain varieties of the Japanese puffer fish. Several quinazoline derivates show antimalarial properties against Plasmodium gallinace-um. The most effective was 6-chloro-2-ethyl-3,4-dihydro-4-oxo-3-/7-pyrimidin-2 -ylsulfa-moylphenylquinazoline [28]. 

Delle Monache, F., F. Marletti, and G. Marini-Bettolo Coumarins of Hortia arborea (Rutaceae) Hortiline and Hortiolone. Gazzetta 106, 681 (1976). 

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