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Hypoglycemic agents, oral biguanides

Yet another example of a so-called pharmacophoric group is the biguanide functionality, a grouping associated with oral antidiabetic activity (see the section on sulfonylureas for a fuller discussion of this activity). Condensation of 2-phenethylamine with dicyanamide affords directly the orally active hypoglycemic agent phenformin (88). ... [Pg.75]

Phenformin (27) used clinically as an oral hypoglycemic agent, in common with the biguanides, degrades on volatilization. [Pg.307]

NONCYCLIC ALIPHATICS Many of the biguanides have oral hypoglycemic activity, and metformin (87) is such an antidiabetic agent. Cyanamide has a highly reactive nitrile function because of the electropositive NH2 group... [Pg.20]

See other pages where Hypoglycemic agents, oral biguanides is mentioned: [Pg.73]    [Pg.521]    [Pg.773]    [Pg.272]    [Pg.459]    [Pg.488]    [Pg.258]    [Pg.284]    [Pg.284]    [Pg.284]   
See also in sourсe #XX -- [ Pg.869 ]



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Biguanide

Biguanides, Oral hypoglycemic

Hypoglycemic

Hypoglycemic agents

Hypoglycemics

Hypoglycemics, oral

Oral hypoglycemic agents

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